CLINOFIBRATE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C28H36O6
Molecular Weight	468.5818
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(C)(OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(OC(C)(CC)C(O)=O)C=C3)C(O)=O

InChI

InChIKey=BMOVQUBVGICXQN-UHFFFAOYSA-N

InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)

HIDE SMILES / InChI

Molecular Formula	C28H36O6
Molecular Weight	468.5818
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.google.com/patents/US20110269141

Clinofibrate is known as a fibrate therapeutic drug for hyperlipidemia.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Peroxisome proliferator-activated receptor alpha 62 Target ID: Q07869 Gene ID: 5465.0 Gene Symbol: PPARA Target Organism: Homo sapiens (Human) Sources: http://www.springer.com/us/book/9781461475538	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hyperlipidemia 80 Sources: http://www.229877.com/article/2013/0823/33410.html	Primary		Approved 8429	LIPOCLIN Approved Use It is usually used to treat hyperlipidemia.

PubMed

Title	Date	PubMed
Effects of some hypolipidemic agents on biochemical values and hepatic peroxisomal enzymes in rats: comparison of probucol, CGA, KCD-232, MLM-160, AL-369 and clinofibrate with clofibrate.	1987 Mar	3625448
[Usefulness of examination of the cholesterol versus triglyceride ratio for lipoprotein fractions in a patient with marked hyper-triglyceridemia].	2002 Oct	12451680
Flow cytometric evaluation of synergistic pro-apoptotic effects of statins and clofibrates in IM-9 human lymphoblasts.	2007 Sep	17645633
4,4'-(Cyclo-hexane-1,1-di-yl)diphenol methanol solvate.	2009 Jan 10	21581883
In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities.	2010 Dec	20810539

Patents

Sample Use Guides

In Vivo Use Guide

For adults, take 1 tablet (200mg of the active ingredient) at a time, 3 times a day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:09:56 GMT 2023` Edited by `admin` on `Fri Dec 15 16:09:56 GMT 2023`
Record UNII	0374EZJ8CU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLINOFIBRATE

Official Name

English

2,2'-(CYCLOHEXYLIDENEBIS(P-PHENYLENEOXY))BIS(2-METHYLBUTYRIC ACID)

Common Name

English

CLINOFIBRATE [JAN]

Common Name

English

Clinofibrate [WHO-DD]

Common Name

English

clinofibrate [INN]

Common Name

English

CLINOFIBRATE [MI]

Common Name

English

CLINOFIBRATE [MART.]

Common Name

English

LIPOCLIN

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98150