Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H23N3 |
Molecular Weight | 305.4167 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCCN1C2=C(CCC3=C1C=C(C=C3)C#N)C=CC=C2
InChI
InChIKey=LQXYCDLHSKICDY-UHFFFAOYSA-N
InChI=1S/C20H23N3/c1-22(2)12-5-13-23-19-7-4-3-6-17(19)10-11-18-9-8-16(15-21)14-20(18)23/h3-4,6-9,14H,5,10-13H2,1-2H3
Molecular Formula | C20H23N3 |
Molecular Weight | 305.4167 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Cianopramine is a highly potent inhibitor of neuronal serotonin (5-HT) uptake developed by Hoffmann-La Roche for major depression treatment. In preclinical studies, acute and chronic treatment with Cianopramine shows clear behavioural effects Cianopramine increases neophobic reactions in the free exploration test, the avoidance reaction to a brightly illuminated chamber in the light/dark choice procedure as well as to open arms in the elevated plus-maze test. In a double-blind trial, Cianopramine effective in reducing scores on the Hamilton Psychiatric Rating Scale for Depression and on a global scale. Unfortunately, Cianopramine administrations were associated with significant adverse effects and future development was discontinued.
CNS Activity
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies. | 2002 May |
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Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey. | 2007 Sep 21 |
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Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram. | 2008 Mar 31 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3382461
Curator's Comment: https://www.ncbi.nlm.nih.gov/pubmed/6478739
2 mg for 3 weeks
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 15:59:23 GMT 2023
by
admin
on
Sat Dec 16 15:59:23 GMT 2023
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Record UNII |
02MNR4P2PM
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C66885
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48126
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02MNR4P2PM
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C024316
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C80767
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DTXSID90216956
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SUB06227MIG
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100000081881
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Cianopramine
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66834-24-0
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5185
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CHEMBL2106504
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Related Record | Type | Details | ||
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ACTIVE MOIETY |