U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C6H6O3
Molecular Weight 126.11
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYROGALLOL

SMILES

OC1=CC=CC(O)=C1O

InChI

InChIKey=WQGWDDDVZFFDIG-UHFFFAOYSA-N
InChI=1S/C6H6O3/c7-4-2-1-3-5(8)6(4)9/h1-3,7-9H

HIDE SMILES / InChI

Molecular Formula C6H6O3
Molecular Weight 126.11
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Doses

Doses

DosePopulationAdverse events​
10 % 1 times / day multiple, topical
Dose: 10 %, 1 times / day
Route: topical
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy, 77 years
n = 1
Health Status: unhealthy
Condition: Psoriasis
Age Group: 77 years
Sex: M
Population Size: 1
Sources:
Disc. AE: Squamous cell carcinoma...
AEs leading to
discontinuation/dose reduction:
Squamous cell carcinoma
Sources:
10 g single, topical
Dose: 10 g
Route: topical
Route: single
Dose: 10 g
Sources:
unknown
n = 1
Other AEs: Adverse event...
AEs

AEs

AESignificanceDosePopulation
Squamous cell carcinoma Disc. AE
10 % 1 times / day multiple, topical
Dose: 10 %, 1 times / day
Route: topical
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy, 77 years
n = 1
Health Status: unhealthy
Condition: Psoriasis
Age Group: 77 years
Sex: M
Population Size: 1
Sources:
Adverse event grade 5
10 g single, topical
Dose: 10 g
Route: topical
Route: single
Dose: 10 g
Sources:
unknown
n = 1
PubMed

PubMed

TitleDatePubMed
Asaricin, the main component of Ocotea opifera Mart. essential oil.
2001
Influence of culture conditions on the DNA-damaging effect of benzene and its metabolites in human peripheral blood mononuclear cells.
2001
Structural and kinetic characterization of native laccases from Pleurotus ostreatus, Rigidoporus lignosus, and Trametes trogii.
2001 Apr
Amine oxidase-like activity of polyphenols. Mechanism and properties.
2001 Apr
Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase.
2001 Feb
Measurement of dissolved oxygen based on enhanced cerium(IV) chemiluminescence.
2001 Jan
Effects of pH and metal ions on antioxidative activities of catechins.
2001 Jan
Impairment of endothelial nitric oxide production by acute glucose overload.
2001 Jan
Nitric oxide generation in aqueous solutions of cigarette smoke and approaches to its origin.
2001 Nov
Nitric oxide donors retard wound healing in cultured rabbit gastric epithelial cell monolayers.
2001 Nov
Hydrogen-bonded molecular capsules are stable in polar media.
2001 Nov 21
Release of iron from ferritin by metabolites of benzene and superoxide radical generating agents.
2001 Nov 30
[Biological analysis of proteinuria in the laboratory: quantitative features].
2001 Nov-Dec
The antioxidant effect of rebamipide on oxygen free radical production by H. pylori-activated human neutrophils: in comparison with N-acetylcysteine, ascorbic acid and glutathione.
2001 Oct
Effects of agents that inactivate free radical NO (NO*) on nitroxyl anion-mediated relaxations, and on the detection of NO* released from the nitroxyl anion donor Angeli's salt.
2001 Oct
Oxidative stress contributes to vascular endothelial dysfunction in heart failure.
2001 Oct
Dimethoxyphenol oxidase activity of different microbial blue multicopper proteins.
2001 Oct 16
Extractive spectrophotometric determination of antiallergic drugs in pharmaceutical formulations using bromopyrogallol red and bromothymol blue.
2001 Sep
Flow-injection electrogenerated chemiluminescence determination of isoniazid using luminol.
2001 Sep
[Comment on the contribution by P. Gottlober et al.: "Allergic contact dermatitis in beauty shop customers"].
2001 Sep
Blood copper concentrations and cuproenzyme activities in a colony of cats.
2002
Ab initio study of the mechanism of singlet-dioxygen addition to hydroxyaromatic compounds: negative evidence for the involvement of peroxa and endoperoxide intermediates.
2002 Aug
Potentiometric and (1)H NMR studies of complexation of Al(3+) with (-)-epigallocatechin gallate, a major active constituent of green tea.
2002 Jan 1
Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: effects on in vitro cell growth of human tumor cell lines.
2002 Jul
Effect of drying method on the volatiles in bay leaf (Laurus nobilis L.).
2002 Jul 31
Diphenol activation of the monophenolase and diphenolase activities of field bean (Dolichos lablab) polyphenol oxidase.
2002 Mar 13
Isolation from a shea cake digester of a tannin-degrading Streptococcus gallolyticus strain that decarboxylates protocatechuic and hydroxycinnamic acids, and emendation of the species.
2002 May
Flow-injection spectrophotometric determination of periodate and iodate by their reaction with pyrogallol red in acidic media.
2002 Nov
Purification and characterization of an extracellular laccase from the edible mushroom Lentinula edodes, and decolorization of chemically different dyes.
2002 Nov
Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.
2002 Oct
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin.
2003 Feb 3
Method for analysis of tannic acid and its metabolites in biological samples: application to tannic acid metabolism in the rat.
2003 Jan 1
Antioxidant activity and characterization of volatile constituents of Taheebo (Tabebuia impetiginosa Martius ex DC).
2003 Jan 1
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:18:45 GMT 2023
Edited
by admin
on Fri Dec 15 15:18:45 GMT 2023
Record UNII
01Y4A2QXY0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PYROGALLOL
HSDB   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
PYROGALLOL [MI]
Common Name English
PYROGALLOL [MART.]
Common Name English
PYROGALLOL [HSDB]
Common Name English
PYROGALLOL [INCI]
Common Name English
PYROGALLOL [VANDF]
Common Name English
PYROGALLIC ACID
Common Name English
Pyrogallol [WHO-DD]
Common Name English
1,2,3-TRIHYDROXYBENZENE
Systematic Name English
NSC-5035
Code English
Code System Code Type Description
NCI_THESAURUS
C80909
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
CAS
87-66-1
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
SMS_ID
100000078934
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
MESH
D011748
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
ECHA (EC/EINECS)
201-762-9
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
FDA UNII
01Y4A2QXY0
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
CHEBI
16164
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
MERCK INDEX
m9382
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Pyrogallol
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID6025983
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
CONCEPT Industrial Aid
PUBCHEM
1057
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
ChEMBL
CHEMBL307145
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
RXCUI
9022
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY RxNorm
EVMPD
SUB15064MIG
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
NSC
5035
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
HSDB
794
Created by admin on Fri Dec 15 15:18:45 GMT 2023 , Edited by admin on Fri Dec 15 15:18:45 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
PARENT -> CONSTITUENT ALWAYS PRESENT
Pyrogallol content for water extract of plant leaf was 951.27+/-1.12 and plant callus was 40.72+/-0.44 expressed as mg/100 g of dry base of extract. For the analysis of phenolic acids, a Nova pack C18 UG120 equipped with a Guard column, a JASCO HPLC system consisting of a column oven, a UV-Vis diode array detector set at 280 nm, a Liquid chromatography pump and a ChromNAV software program were used.
PARENT -> CONSTITUENT ALWAYS PRESENT