CLOMETHERONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H31ClO2
Molecular Weight	362.933
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@H](C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C[C@H](Cl)C4=CC(=O)CC[C@]34C

InChI

InChIKey=UMRURYMAPMZKQO-NDKKBYRMSA-N

InChI=1S/C22H31ClO2/c1-12-9-17-15-11-19(23)18-10-14(25)5-7-21(18,3)16(15)6-8-22(17,4)20(12)13(2)24/h10,12,15-17,19-20H,5-9,11H2,1-4H3/t12-,15-,16+,17+,19+,20-,21-,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H31ClO2
Molecular Weight	362.933
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14056429 | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.1970.tb08003.x

Clometherone is an investigational derivative of progesterone, possessing antiestrogen and antiandrogen activities. It was developed by Eli Lilly in the 1960s and was found to significantly suppress the estrone induced uterine hypertrophy in mice at an oral or subcutaneous dose of 10ug. In a clinical trial, administration of clometherone to adult males lead to a slight increase in sebum production.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:01:56 GMT 2023` Edited by `admin` on `Sat Dec 16 18:01:56 GMT 2023`
Record UNII	01L3E93T4C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOMETHERONE

Official Name

English

PREGN-4-ENE-3,20-DIONE, 6-CHLORO-16-METHYL-, (6.ALPHA.,16.ALPHA.)-

Systematic Name

English

6α-Chloro-16α-methylpregn-4-ene-3,20-dione

Systematic Name

English

CLOMETHERONE [USAN]

Common Name

English

clometerone [INN]

Common Name

English

CLOMETERONE

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C481