Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H25N3O |
Molecular Weight | 335.4427 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CN(CC3=CC=CC=C3)C[C@]([H])(CN(C1)C(=O)C4=CC=C(N)C=C4)C2
InChI
InChIKey=DLNAKYFPFYUBDR-HDICACEKSA-N
InChI=1S/C21H25N3O/c22-20-8-6-19(7-9-20)21(25)24-14-17-10-18(15-24)13-23(12-17)11-16-4-2-1-3-5-16/h1-9,17-18H,10-15,22H2/t17-,18+
Molecular Formula | C21H25N3O |
Molecular Weight | 335.4427 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL240 |
3.6 µM [IC50] | ||
Target ID: CHEMBL1866 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D09758 |
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Target ID: GO:0006814 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8717164 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Effects of the class III antiarrhythmic drug ambasilide on outward currents in human atrial myocytes. | 1996 Jan |
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Clinical potential of emerging antiarrhythmic agents. | 1999 Apr |
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Analysis of the electrophysiological effects of ambasilide, a new antiarrhythmic agent, in canine isolated ventricular muscle and purkinje fibers. | 2000 Feb |
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Effects of ambasilide in isolated perfused guinea pig heart: use dependence. | 2005 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7872187
Cats: ambasilide, 5 mg/kg intravenous (i.v.) bolus plus 5 mg.kg-1.hr-1 i.v. infusion
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10974415
Curator's Comment: The aim of the study was to determine the in vitro rate-dependent cellular electrophysiological effects of ambasilide (10 and 20 uM/L), a new investigational antiarrhythmic agent, in canine isolated ventricular muscle and Purkinje fibers by applying the standard microelectrode technique. At the cycle length (CL) of 1000 ms, ambasilide significantly prolonged the action potential duration measured at 90% repolarization (APD(90)) in both ventricular muscle and Purkinje fibers.
Ambasilide (10 uM/L) produced a more marked prolongation of APD(90) at lower stimulation frequencies in Purkinje fibers (at CL of 2000 ms = 56.0 +/- 16.1%, n = 6, versus CL of 400 ms = 15.1 +/- 3.7%, n = 6; p < 0.05), but, in 20 microM/l, this effect was considerably diminished (15.2 +/- 3.6%, n = 6, versus 7.3 +/- 5.1%, n = 6, p < 0.05).
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:19:05 GMT 2023
by
admin
on
Fri Dec 15 16:19:05 GMT 2023
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Record UNII |
012LYD6KXM
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Record Status |
Validated (UNII)
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Record Version |
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Official Name | English | ||
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NCI_THESAURUS |
C47793
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10449626
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DTXSID0057839
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C72573
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CHEMBL2107656
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100000087648
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C075113
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SUB05393MIG
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012LYD6KXM
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83991-25-7
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Related Record | Type | Details | ||
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ACTIVE MOIETY |