ALFADOLONE ACETATE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H34O5
Molecular Weight	390.5131
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](C(=O)COC(C)=O)[C@@]1(C)CC(=O)[C@@]3([H])[C@@]2([H])CC[C@@]4([H])C[C@H](O)CC[C@]34C

InChI

InChIKey=QRJOQYLXZPQQMX-FWROMSNXSA-N

InChI=1S/C23H34O5/c1-13(24)28-12-20(27)18-7-6-17-16-5-4-14-10-15(25)8-9-22(14,2)21(16)19(26)11-23(17,18)3/h14-18,21,25H,4-12H2,1-3H3/t14-,15+,16-,17-,18+,21+,22-,23-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H34O5
Molecular Weight	390.5131
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11573627

Alfadolone or alphadolone is an oral neurosteroid, which can be useful as an analgesic.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11573627	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Controlled sedation with alphaxalone-alphadolone.	1974 Jun 22	4835444
Antinociceptive properties of neurosteroids IV: pilot study demonstrating the analgesic effects of alphadolone administered orally to humans.	2001 Apr	11573627
Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically.	2001 May	11575348
Prevention and reversal of morphine tolerance by the analgesic neuroactive steroid alphadolone.	2009 Jul-Aug	19682273

Sample Use Guides

In Vivo Use Guide

alphadolone (25-500 mg, n = 9) or placebo (lactose, n = 5) given orally 1 h after operation

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:58:56 GMT 2023` Edited by `admin` on `Fri Dec 15 16:58:56 GMT 2023`
Record UNII	00TN4GS00S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALFADOLONE ACETATE

Common Name

English

ALFADOLONE ACETATE [MI]

Common Name

English

Alfadolone acetate [WHO-DD]

Common Name

English

ALFADOLONE ACETATE [MART.]

Common Name

English

ALPHADOLONE ACETATE

Common Name

English

PREGNANE-11,20-DIONE, 21-(ACETYLOXY)-3-HYDROXY-, (3.ALPHA.,5.ALPHA.)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241