ALFADOLONE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H32O4
Molecular Weight	348.4764
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(C)CC(=O)[C@@]3([H])[C@@]2([H])CC[C@@]4([H])C[C@H](O)CC[C@]34C

InChI

InChIKey=XWYBFXIUISNTQG-VKMGZQQJSA-N

InChI=1S/C21H32O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-16,19,22-23H,3-11H2,1-2H3/t12-,13+,14-,15-,16+,19+,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H32O4
Molecular Weight	348.4764
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11573627

Alfadolone or alphadolone is an oral neurosteroid, which can be useful as an analgesic.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11573627	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Controlled sedation with alphaxalone-alphadolone.	1974 Jun 22	4835444
Antinociceptive properties of neurosteroids IV: pilot study demonstrating the analgesic effects of alphadolone administered orally to humans.	2001 Apr	11573627
Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically.	2001 May	11575348
Prevention and reversal of morphine tolerance by the analgesic neuroactive steroid alphadolone.	2009 Jul-Aug	19682273

Sample Use Guides

In Vivo Use Guide

alphadolone (25-500 mg, n = 9) or placebo (lactose, n = 5) given orally 1 h after operation

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:15:22 UTC 2023` Edited by `admin` on `Sat Dec 16 16:15:22 UTC 2023`
Record UNII	OE1C96974E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALFADOLONE

Official Name

English

3.ALPHA.,21-DIHYDROXY-5.ALPHA.-PREGNANE-11,20-DIONE

Systematic Name

English

ALPHADOLONE

Common Name

English

Alfadolone [WHO-DD]

Common Name

English

GR-2/1574

Code

English

alfadolone [INN]

Common Name

English

GR 2/1574

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C241