Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | V |
| Molecular Weight | 50.9415 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[V]
InChI
InChIKey=LEONUFNNVUYDNQ-UHFFFAOYSA-N
InChI=1S/V
| Molecular Formula | V |
| Molecular Weight | 50.9415 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
http://www.hmdb.ca/metabolites/HMDB02503 | https://www.ncbi.nlm.nih.gov/mesh/68014639 | https://www.ncbi.nlm.nih.gov/pubmed/12050018
Curator's Comment: description was created based on several sources, including
http://www.hmdb.ca/metabolites/HMDB02503 | https://www.ncbi.nlm.nih.gov/mesh/68014639 | https://www.ncbi.nlm.nih.gov/pubmed/12050018
Vanadium (V) is a steel-grey, corrosion-resistant metal. Because of its hardness and its ability to form alloys, vanadium (i.e., ferrovanadium) is a common component of hard steel alloys used in machines and tools. Although most foods contain low concentrations of vanadium (< 1 ng/g), food is the major source of exposure to vanadium for the general population. Vanadium is probably an essential trace element, but a vanadium-deficiency disease has not been identified in humans. At pharmacological doses, vanadium compounds display relevant biological actions such as mimicking insulin and growth factors as well as having osteogenic activity. Some vanadium compounds also show antitumoral properties.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Modulation of cytochrome P450 1 (Cyp1) by vanadium in hepatic tissue and isolated hepatocyte of C57BL/6 mice. | 2013-08 |
|
| Nicotine attenuates spatial learning deficits induced by sodium metavanadate. | 2012-01 |
|
| Transcriptional and posttranscriptional regulation of CYP1A1 by vanadium in human hepatoma HepG2 cells. | 2010-10 |
|
| Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells. | 2009-05-01 |
|
| Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice. | 2009-03 |
|
| Endothelial effects of emission source particles: acute toxic response gene expression profiles. | 2009-02 |
|
| Down-regulation of the carcinogen-metabolizing enzyme cytochrome P450 1a1 by vanadium. | 2008-09 |
|
| Source apportionment of particulate matter in the U.S. and associations with lung inflammatory markers. | 2008-05 |
|
| Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction. | 2008-02-29 |
|
| Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats. | 2007-05-01 |
|
| Upregulation of LITAF mRNA expression upon exposure to TiAlV and polyethylene wear particles in THP-1 macrophages. | 2007-04 |
|
| Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process. | 2007-01 |
|
| Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats. | 2006-10 |
|
| Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression. | 2006-10 |
|
| Vanadium and insulin increase adiponectin production in 3T3-L1 adipocytes. | 2006-07 |
|
| Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. | 2006-06-15 |
|
| Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model. | 2006-05-08 |
|
| Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and -2 and iNOS expression during ongoing alteration in iron homeostasis. | 2006-05 |
|
| Oral vanadium enhances the catabolic effects of central leptin in young adult rats. | 2006-01 |
|
| Divalent metal transporter-1 decreases metal-related injury in the lung. | 2005-09 |
|
| Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor. | 2005-08 |
|
| Vanadium induces apoptosis and modulates the expressions of metallothionein, Ki-67 nuclear antigen, and p53 during 2-acetylaminofluorene-induced rat liver preneoplasia. | 2005-03-01 |
|
| [Regulatory effects of micronutrient complex on the expression of Th1 and Th2 cytokines in diabetic C57BL mice]. | 2005-01 |
|
| Protective role of vanadium on the early process of rat mammary carcinogenesis by influencing expression of metallothionein, GGT-positive foci and DNA fragmentation. | 2004-11-27 |
|
| Metal particulate matter components affect gene expression and beat frequency of neonatal rat ventricular myocytes. | 2004-05 |
|
| Vanadium--an element of atypical biological significance. | 2004-04-21 |
|
| Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells. | 2004-01 |
|
| Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and phosphatidylinositol 3-kinase by vanadyl sulfate, a protein tyrosine phosphatase inhibitor. | 2003-12-01 |
|
| Novel vanadium-binding proteins (vanabins) identified in cDNA libraries and the genome of the ascidian Ciona intestinalis. | 2003-11-30 |
|
| Differential ability of transition metals to induce pulmonary inflammation. | 2001-11-15 |
|
| Trace elements in regulation of NF-kappaB activity. | 2000-10 |
|
| Effect of peroxovanadate compound on phenylalanine hydroxylase gene expression. | 2000-06 |
|
| Lung mucin production is stimulated by the air pollutant residual oil fly ash. | 2000-01-15 |
|
| Inhibition of HIV-1 infection by zinc group metal compounds. | 1999-09 |
|
| Vanadium: a review of its potential role in the fight against diabetes. | 1999-06 |
|
| Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. | 1998-06 |
|
| Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent. | 1997-10 |
|
| Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital. | 1995-06 |
|
| Minerals in the municipal water and atherosclerotic heart death. | 1971-04 |
Patents
Sample Use Guides
Tolerable upper intake level for adults is 1.8 mg/day.
Route of Administration:
Oral
Vanadate (V) ions competitively inhibit calf thymus terminal deoxynucleotidyl transferase with Ki = 2.5 microM. A binding of vanadium to the enzyme with no change of the amount of the Zn constituent of the protein was found at concentrations of vanadate causing inhibition. The catalytic activity of mammalian DNA polymerase alpha was also inhibited by vanadate ions at an I50 of 60 microM, while the bacterial (E. coli) DNA polymerase I was affected to the same extent only when the concentration of vanadate was raised to about 0.5 mM. In contrast to the inhibitory effects caused by vanadium on the nucleotidyl transferases, concentrations of pentavalent vanadium ions of the order of 10 microM increase 2.4-fold the hydrolytic activity of deoxyribonuclease I from bovine pancreas.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:36:02 GMT 2025
by
admin
on
Mon Mar 31 18:36:02 GMT 2025
|
| Record UNII |
00J9J9XKDE
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
DSLD |
132 (Number of products:1869)
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
7440-62-2
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
DB13971
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
m11374
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | Merck Index | ||
|
231-171-1
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
1022
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
100000129113
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
27698
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
D014639
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
C68292
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
00J9J9XKDE
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
11121
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | RxNorm | ||
|
23990
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
00J9J9XKDE
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
35170
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
DTXSID2040282
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY | |||
|
SUB37143
Created by
admin on Mon Mar 31 18:36:02 GMT 2025 , Edited by admin on Mon Mar 31 18:36:02 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
