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Details

Stereochemistry ACHIRAL
Molecular Formula V
Molecular Weight 50.9415
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VANADIUM

SMILES

[V]

InChI

InChIKey=LEONUFNNVUYDNQ-UHFFFAOYSA-N
InChI=1S/V

HIDE SMILES / InChI

Molecular Formula V
Molecular Weight 50.9415
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Vanadium (V) is a steel-grey, corrosion-resistant metal. Because of its hardness and its ability to form alloys, vanadium (i.e., ferrovanadium) is a common component of hard steel alloys used in machines and tools. Although most foods contain low concentrations of vanadium (< 1 ng/g), food is the major source of exposure to vanadium for the general population. Vanadium is probably an essential trace element, but a vanadium-deficiency disease has not been identified in humans. At pharmacological doses, vanadium compounds display relevant biological actions such as mimicking insulin and growth factors as well as having osteogenic activity. Some vanadium compounds also show antitumoral properties.

CNS Activity

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Tolerable upper intake level for adults is 1.8 mg/day.
Route of Administration: Oral
In Vitro Use Guide
Vanadate (V) ions competitively inhibit calf thymus terminal deoxynucleotidyl transferase with Ki = 2.5 microM. A binding of vanadium to the enzyme with no change of the amount of the Zn constituent of the protein was found at concentrations of vanadate causing inhibition. The catalytic activity of mammalian DNA polymerase alpha was also inhibited by vanadate ions at an I50 of 60 microM, while the bacterial (E. coli) DNA polymerase I was affected to the same extent only when the concentration of vanadate was raised to about 0.5 mM. In contrast to the inhibitory effects caused by vanadium on the nucleotidyl transferases, concentrations of pentavalent vanadium ions of the order of 10 microM increase 2.4-fold the hydrolytic activity of deoxyribonuclease I from bovine pancreas.
Substance Class Chemical
Record UNII
00J9J9XKDE
Record Status Validated (UNII)
Record Version