TIPROPIDIL

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H35NO2S
Molecular Weight	353.562
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCNCC(O)COC1=CC=C(SC(C)C)C=C1

InChI

InChIKey=ZAPDURRCHSKKKK-UHFFFAOYSA-N

InChI=1S/C20H35NO2S/c1-4-5-6-7-8-9-14-21-15-18(22)16-23-19-10-12-20(13-11-19)24-17(2)3/h10-13,17-18,21-22H,4-9,14-16H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C20H35NO2S
Molecular Weight	353.562
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6278505 | DOI:10.1016/S0065-7743(08)60493-5 | https://www.ncbi.nlm.nih.gov/pubmed/6329057

Tipropidil designed for the treatment of cerebral and peripheral vascular diseases. Tipropidil has been investigated because of its expected antihyperviscosity properties. The increase in plasma free fatty acid levels and decrease in lipolytic response were found to be dependent on the amount of Tipropidil administered. Addition of Tipropidil to the in vitro lipolysis system inhibited norepinephrine- and theophylline-induced fatty acid release in a dose-dependent manner. These results suggest a potent inhibitory action for Tipropidyl on fatty acid mobilization in rat adipose tissue.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
lipid metabolic process 22 Target ID: GO:0006629 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6278505	Modulator 846

PubMed

Title	Date	PubMed
Action of drugs on the aggregation and deformability of red cells: effect of ABO blood groups.	1983	6329057
Effect of vasoactive agents on fatty acid metabolism: inhibition of lipolysis by tipropidil in rat epididymal adipose tissue.	1982-01	6278505

Sample Use Guides

In Vivo Use Guide

Single dose - 50 mg/kg body wt

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:24:33 GMT 2025` Edited by `admin` on `Mon Mar 31 18:24:33 GMT 2025`
Record UNII	007QF56M4D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(P-(ISOPROPYLTHIO)PHENOXY)-3-(OCTYLAMINO)-2-PROPANOL

Preferred Name

English

TIPROPIDIL

Official Name

English

2-PROPANOL, 1-(4-((1-METHYLETHYL)THIO)PHENOXY)-3-(OCTYLAMINO)-

Systematic Name

English

tipropidil [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29707