Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H15N3S |
| Molecular Weight | 161.268 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCCSC(N)=N
InChI
InChIKey=OLHQOJYVQUNWPL-UHFFFAOYSA-N
InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8)
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25524412 | https://www.ncbi.nlm.nih.gov/pubmed/21211106
Curator's Comment: Dimaprit is CNS active in animals. No human data available.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937. | 1997 Jun |
|
| Phe217 regulates the transfer of allosteric information across the subunit interface of the RecA protein filament. | 2001 Jan 10 |
|
| Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum. | 2001 Jul |
|
| Cloning and characterization of a novel human histamine receptor. | 2001 Mar |
|
| Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. | 2001 Mar 15 |
|
| Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats. | 2001 May 4 |
|
| Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-receptors. | 2001 Sep |
|
| Contractile response of horse deep dorsal penile vein to histamine. | 2002 Apr |
|
| Effects of histamine on the contractile and electrical activity in isolated lymphatic vessels of the guinea-pig mesentery. | 2002 Aug |
|
| Methods to enhance signal using isotopic in situ hybridization. | 2002 Aug |
|
| Accelerated clearance of Escherichia coli in experimental peritonitis of histamine-deficient mice. | 2002 Aug 15 |
|
| Activation of histamine H2 receptors ameliorates experimental allergic encephalomyelitis. | 2002 Aug 7 |
|
| Characteristics of histamine tachyphylaxis in rat uterine smooth muscle. | 2002 Dec |
|
| Further evidence for the involvement of histamine H2 receptors in the control of defensive behaviour generated in the midbrain tectum. | 2002 Feb |
|
| Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists. | 2002 Jun |
|
| Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats. | 2002 May-Jun |
|
| Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. | 2002 Oct |
|
| Histamine H(2) receptor-mediated modulation of local cytokine expression in a mouse experimental tumor model. | 2002 Oct 11 |
|
| Histamine receptor type coupled to nitric oxide-induced relaxation of guinea-pig nasal mucosa. | 2002 Oct-Dec |
|
| Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18. | 2002 Sep 27 |
|
| Differential activation of dual signaling responses by human H1 and H2 histamine receptors. | 2003 Feb |
|
| Histamine inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in an intercellular adhesion molecule-1- and B7.1-dependent manner. | 2003 Feb |
|
| Histamine elicits neuronal excitatory response of red nucleus in the rat via H2 receptors in vitro. | 2003 Nov 6 |
|
| PD-136,450: a CCK2 (gastrin) receptor antagonist with antisecretory, anxiolytic and antiulcer activity. | 2003 Oct |
|
| Histaminergic receptors modulate the coronary vascular response in isolated guinea pig hearts. Role of nitric oxide. | 2003 Sep |
|
| Alleviation of ischemic neuronal damage by histamine H2 receptor stimulation in the rat striatum. | 2004 Jan 26 |
|
| Replacement of amino acid sequence features of a- and c-subunits of ATP synthases of Alkaliphilic Bacillus with the Bacillus consensus sequence results in defective oxidative phosphorylation and non-fermentative growth at pH 10.5. | 2004 Jun 18 |
|
| Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. | 2004 May |
|
| Histamine helps development of eczematous lesions in experimental contact dermatitis in mice. | 2005 Aug |
|
| Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. | 2005 Dec |
|
| Histamine contributes to ischemia-related activation of cardiac spinal afferents: role of H1 receptors and PKC. | 2005 Feb |
|
| Histamine receptors that influence blockage of the normal human nasal airway. | 2005 Mar |
|
| Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro. | 2005 Nov |
|
| Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. | 2006 Apr |
|
| Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism. | 2006 Jul |
|
| Cultured smooth muscle cells of the human vesical sphincter are more sensitive to histamine than are detrusor smooth muscle cells. | 2006 May |
|
| Study on the antinociceptive action of Tyr-K-MIF-1, a peptide from the MIF family. | 2007 Apr |
|
| Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. | 2007 Jun |
|
| Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats. | 2007 Sep |
|
| Olfactory interference during inhibitory backward pairing in honey bees. | 2008 |
|
| The ATPase cycle of the mitochondrial Hsp90 analog Trap1. | 2008 Apr 25 |
|
| The anti-secretory and anti-ulcer activities of esomeprazole in comparison with omeprazole in the stomach of rats and rabbits. | 2008 Feb |
|
| Validation of a conscious rat model for the discovery of novel agents that inhibit gastric acid secretion. | 2008 Jul 28 |
|
| Histamine-induced itch and its relationship with pain. | 2008 Jul 31 |
|
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | 2008 Jun 6 |
|
| Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants. | 2008 Mar 25 |
|
| Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor. | 2009 |
|
| G-protein coupled receptor signaling architecture of mammalian immune cells. | 2009 |
|
| Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430. | 2009 May |
|
| Control of the flow properties of DNA by topoisomerase II and its targeting inhibitor. | 2010 Sep 22 |
Patents
Sample Use Guides
In vitro, dimaprit dose dependently inhibited the production of TNF-alpha in mouse peritoneal macrophages and human peripheral blood monocytes stimulated with lipopolysaccharide with IC50 values of 1 uM.
Dimaprit, added to tumour cell cultures (100 uM), inhibited the incorporation of 3H-thymidine while embryonic cell cultures were unaffected.
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Common Name | English | ||
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| Code System | Code | Type | Description | ||
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DIMAPRIT
Created by
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65119-89-3
Created by
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DTXSID0037154
Created by
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ZZQ699148P
Created by
admin on Fri Dec 15 19:45:56 GMT 2023 , Edited by admin on Fri Dec 15 19:45:56 GMT 2023
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3077
Created by
admin on Fri Dec 15 19:45:56 GMT 2023 , Edited by admin on Fri Dec 15 19:45:56 GMT 2023
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PRIMARY |
ACTIVE MOIETY
