N-ACETYL DIHYDROSPHINGOSINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H41NO3
Molecular Weight	343.5444
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of N-ACETYL DIHYDROSPHINGOSINE

Structure Search

SMILES

CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O

InChI

InChIKey=CRJGESKKUOMBCT-VQTJNVASSA-N

InChI=1S/C20H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h19-20,22,24H,3-17H2,1-2H3,(H,21,23)/t19-,20+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12639542
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/28109750 | https://www.ncbi.nlm.nih.gov/pubmed/11882365 | https://www.ncbi.nlm.nih.gov/pubmed/27475534

N-Acetyl dihydrosphingosine is dihydroceramide derivative and isomer of cedefingol with minimal anticancer activity. N-Acetyl dihydrosphingosine shows minimal apoptotic activity against human leukemia cells.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Porphyromonas gingivalis dihydroceramides induce apoptosis in endothelial cells.	2007 Jul	17586710

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

The apoptotic activities of the N-Acetyl dihydrosphingosine were examined in HL-60 human leukemia cells. HL-60 cells were treated with N-Acetyl dihydrosphingosine for 6 h. Dose-dependent cell killing abilities were confirmed by a MTT assay.

Name

Type

Language

N-ACETYL DIHYDROSPHINGOSINE

Official Name

English

TIC-016

Brand Name

English

ACETAMIDE, N-(2-HYDROXY-1-(HYDROXYMETHYL)HEPTADECYL)-, (R-(R*,S*))-

Common Name

English

D-ERYTHRO-N-ACETYLSPHINGANINE

Common Name

English

D-ERYTHRO-2-ACETAMIDO-1,3-OCTADECANEDIOL

Common Name

English

N-ACETYL DIHYDROSPHINGOSINE [INCI]

Common Name

English

ACETAMIDE, N-((1S,2R)-2-HYDROXY-1-(HYDROXYMETHYL)HEPTADECYL)-

Systematic Name

English

ACETAMIDE, N-(2-HYDROXY-1-(HYDROXYMETHYL)HEPTADECYL)-, D-ERYTHRO-

Common Name

English

DS-N-ACETYLSPHINGANINE

Brand Name

English

N-ACETYLDIHYDROSPHINGOSINE

Common Name

English

D-ERYTHRO-1,3-DIHYDROXY-2-ACETAMIDOOCTADECANE

Common Name

English

Code System Code Type Description

PUBCHEM

6610273