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Details

Stereochemistry ABSOLUTE
Molecular Formula C20H41NO3
Molecular Weight 343.5444
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-ACETYL DIHYDROSPHINGOSINE

SMILES

CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O

InChI

InChIKey=CRJGESKKUOMBCT-VQTJNVASSA-N
InChI=1S/C20H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h19-20,22,24H,3-17H2,1-2H3,(H,21,23)/t19-,20+/m0/s1

HIDE SMILES / InChI
Molecular Formula C20H41NO3
Molecular Weight 343.5444
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

N-Acetyl dihydrosphingosine is dihydroceramide derivative and isomer of cedefingol with minimal anticancer activity. N-Acetyl dihydrosphingosine shows minimal apoptotic activity against human leukemia cells.

Originator

Carter, H.E.|Norris, W.P.|Glick, F.J.|Phillips, G. E.|Harris, R.
1

Approval Year

Unknown
139,594

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Patents

07846969
1
08207370
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
The apoptotic activities of the N-Acetyl dihydrosphingosine were examined in HL-60 human leukemia cells. HL-60 cells were treated with N-Acetyl dihydrosphingosine for 6 h. Dose-dependent cell killing abilities were confirmed by a MTT assay.
Substance Class Chemical
Record UNII
ZZK8X1CR0R
Record Status Validated (UNII)
Record Version
NIH
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