Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H30O4S |
| Molecular Weight | 378.525 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@](O)(C(=O)CS)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C
InChI
InChIKey=YWDBSCORAARPPF-VWUMJDOOSA-N
InChI=1S/C21H30O4S/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-26)20(15,2)10-16(23)18(14)19/h9,14-16,18,23,25-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Tixocortol is a synthetic steroid with topical anti-inflammatory properties. In form of Tixocortol pivalate, also known as Pivalone, it is used to treat the inflammatory and allergic manifestations of the rhino-pharynx: allergic rhinitis, acute and chronic congestive rhinitis, vasomotor rhinitis. In addition, it has been shown to be a useful agent for assessing corticosteroid contact dermatitis, particularly for hydrocortisone-type derivatives. Labeled adverse effects are: itchy nose, dryness of the nasal mucosa, edema of the face mucosa, cataract, glaucoma, Cushing syndrome, skin thinning.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Epidemiologic surveillance of contact allergens. The "monitoring series" of IVDK (Information Network ofDermatologic Clinics for Detection and Scientific Evaluation of Contact Allergy]. | 2003 Aug |
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| [The value of allergy survey in a retrospective series of 40 patients with burning-mouth syndrome (stomatodynia)]. | 2008 Feb |
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| Concordance of patch test results with four new TRUE test allergens compared with the same allergens from Chemotechnique. | 2009 Jan |
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| Positive patch-test reactions to propylene glycol: a retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006. | 2009 Jan-Feb |
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| [Allergic contact dermatitis due to corticosteroids: a 3-year retrospective study in a hospital skin allergy unit]. | 2009 May |
|
| Pattern of corticosteroid allergy in Thailand. | 2010 Jul-Aug |
Patents
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WHO-ATC |
A07EA05
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QR01AD57
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WHO-VATC |
QA07EA05
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QR01AD07
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C211
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WHO-ATC |
R01AD07
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WHO-ATC |
R01AD57
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4064
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C152667
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m10911
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57257
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CHEMBL2107112
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ZX3KEK657Z
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TIXOCORTOL
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4125
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SUB11127MIG
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ZX3KEK657Z
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C040971
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DB09091
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61951-99-3
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ACTIVE MOIETY
