GR-113808

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H27N3O4S
Molecular Weight	393.5
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C=C(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)C3=C1C=CC=C3

InChI

InChIKey=MOZPSIXKYJUTKI-UHFFFAOYSA-N

InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
Serotonin 4 (5-HT4) receptor 38 Target ID: CHEMBL1875 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9349523 \| https://www.ncbi.nlm.nih.gov/pubmed/8012715	Antagonist 2849	0.15 nM [Kd]
Beta-1 adrenergic receptor 163 Target ID: CHEMBL3252 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8012715	Binding Agent 1076	5.1 null [pKi]
Muscarinic acetylcholine receptor M1 168 Target ID: CHEMBL276 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8012715	Binding Agent 1076	5.2 null [pKi]

PubMed

Title	Date	PubMed
Effects of 5-HT in globus pallidus on haloperidol-induced catalepsy in rats.	2009-04-17	19429052
Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-HT4) receptors.	2009-03	18948374
New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket.	2004-10	15351779
Regulation of ion transport by 5-hydroxytryptamine in rat colon.	2004-07	15236628
Mechanism of action of the cisapride-induced vasodilatation in renal vasculature of rat.	2004-03	15115163
BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse.	2003-06	12736770
5-HT decreases contractile and electrical activities in lymphatic vessels of the guinea-pig mesentery: role of 5-HT 7-receptors.	2003-05	12770929
5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs.	2003-02-14	12586216
New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization.	2003-01-02	12502367
Central 5-HT(4) receptors and dopamine-dependent motor behaviors: searching for a functional role.	2002-04	11888554
5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.	2001-02	11218067
New arylpiperazine derivatives as antagonists of the human cloned 5-HT(4) receptor isoforms.	2000-10-05	11020291
Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.	2000-10	11030734
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.	2000-02	10646498
Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.	1998-06	9603189
Cloning and expression of a human serotonin 5-HT4 receptor cDNA.	1997-11	9349523
Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.	1997-10-20	9351641
[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors.	1997-04-01	9225293
Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.	1996-11-25	8946946

Name

Type

Language

1H-INDOLE-3-CARBOXYLIC ACID, 1-METHYL-, (1-(2-((METHYLSULFONYL)AMINO)ETHYL)-4-PIPERIDINYL)METHYL ESTER

Preferred Name

English

GR-113808

Common Name

English

Code System Code Type Description

FDA UNII

ZT350OYT3I