GR-113808

CN1C=C(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)C3=CC=CC=C13

InChIKey=MOZPSIXKYJUTKI-UHFFFAOYSA-N

InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Serotonin 4 (5-HT4) receptor 39 Target ID: CHEMBL1875 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9349523 \| https://www.ncbi.nlm.nih.gov/pubmed/8012715	Antagonist 2778	0.15 nM [Kd]
Beta-1 adrenergic receptor 158 Target ID: CHEMBL3252 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8012715	Binding Agent 1064	5.1 null [pKi]
Muscarinic acetylcholine receptor M1 169 Target ID: CHEMBL276 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8012715	Binding Agent 1064	5.2 null [pKi]

PubMed

Title	Date	PubMed
Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.	1996 Nov 25	8946946
[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors.	1997 Apr-May	9225293
Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.	1997 Oct 20	9351641
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.	2000 Feb	10646498
Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.	2000 Oct	11030734
BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse.	2003 Jun	12736770
5-HT decreases contractile and electrical activities in lymphatic vessels of the guinea-pig mesentery: role of 5-HT 7-receptors.	2003 May	12770929
Mechanism of action of the cisapride-induced vasodilatation in renal vasculature of rat.	2004 Mar	15115163
New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket.	2004 Oct	15351779
Effects of 5-HT in globus pallidus on haloperidol-induced catalepsy in rats.	2009 Apr 17	19429052
Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-HT4) receptors.	2009 Mar	18948374

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:16:49 GMT 2023` Edited by `admin` on `Sat Dec 16 09:16:49 GMT 2023`
Record UNII	ZT350OYT3I
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

GR-113808

Common Name

English

1H-INDOLE-3-CARBOXYLIC ACID, 1-METHYL-, (1-(2-((METHYLSULFONYL)AMINO)ETHYL)-4-PIPERIDINYL)METHYL ESTER

Systematic Name

English

Code System Code Type Description

FDA UNII

ZT350OYT3I