Details
Stereochemistry | ACHIRAL |
Molecular Formula | C19H27N3O4S |
Molecular Weight | 393.5 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C=C(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)C3=CC=CC=C13
InChI
InChIKey=MOZPSIXKYJUTKI-UHFFFAOYSA-N
InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
Molecular Formula | C19H27N3O4S |
Molecular Weight | 393.5 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1875 |
0.15 nM [Kd] | ||
Target ID: CHEMBL3252 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8012715 |
5.1 null [pKi] | ||
Target ID: CHEMBL276 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8012715 |
5.2 null [pKi] |
PubMed
Title | Date | PubMed |
---|---|---|
Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor. | 1996 Nov 25 |
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Cloning and expression of a human serotonin 5-HT4 receptor cDNA. | 1997 Nov |
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Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase. | 1997 Oct 20 |
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Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. | 1998 Jun |
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5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. | 2001 Feb |
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Central 5-HT(4) receptors and dopamine-dependent motor behaviors: searching for a functional role. | 2002 Apr |
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New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization. | 2003 Jan 2 |
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BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse. | 2003 Jun |
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Regulation of ion transport by 5-hydroxytryptamine in rat colon. | 2004 Jul |
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New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket. | 2004 Oct |
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Effects of 5-HT in globus pallidus on haloperidol-induced catalepsy in rats. | 2009 Apr 17 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:16:49 UTC 2023
by
admin
on
Sat Dec 16 09:16:49 UTC 2023
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Record UNII |
ZT350OYT3I
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Record Status |
Validated (UNII)
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Record Version |
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119376
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144625-51-4
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DTXSID40162772
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