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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H28N2O5.ClH
Molecular Weight 460.95
Optical Activity ( + )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENAZEPRIL HYDROCHLORIDE, (R,R)-

SMILES

Cl.CCOC(=O)[C@@H](CCC1=CC=CC=C1)N[C@@H]2CCC3=CC=CC=C3N(CC(O)=O)C2=O

InChI

InChIKey=VPSRQEHTHIMDQM-GZJHNZOKSA-N
InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m1./s1

HIDE SMILES / InChI
Benazepril Related Compound A, it is an Impurity. Benazepril is a prodrug which is metabolized by the liver into its active form benazeprilat via cleavage of the drug's ester group. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. Benazeprilat has much greater ACE inhibitory activity than does Benazepril. It is indicated for the treatment of hypertension.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
BENAZEPRIL HYDROCHLORIDE, (R,R)-
Common Name English
BENAZEPRIL RELATED COMPOUND A
USP  
Preferred Name English
Benazepril Related Compound A [USP-RS]
Common Name English
2-[(R)-3-{[(R)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl]acetic acid hydrochloride
Systematic Name English
(3R) 3-[[(1R)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid, monohydrochloride
Systematic Name English
1H-1-BENZAZEPINE-1-ACETIC ACID, 3-(((1R)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)-2,3,4,5-TETRAHYDRO-2-OXO-, MONOHYDROCHLORIDE, (3R)-
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID80175881
Created by admin on Mon Mar 31 21:40:21 GMT 2025 , Edited by admin on Mon Mar 31 21:40:21 GMT 2025
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PUBCHEM
56924237
Created by admin on Mon Mar 31 21:40:21 GMT 2025 , Edited by admin on Mon Mar 31 21:40:21 GMT 2025
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RS_ITEM_NUM
1048620
Created by admin on Mon Mar 31 21:40:21 GMT 2025 , Edited by admin on Mon Mar 31 21:40:21 GMT 2025
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CAS
215447-89-5
Created by admin on Mon Mar 31 21:40:21 GMT 2025 , Edited by admin on Mon Mar 31 21:40:21 GMT 2025
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FDA UNII
ZGK2LDW9PT
Created by admin on Mon Mar 31 21:40:21 GMT 2025 , Edited by admin on Mon Mar 31 21:40:21 GMT 2025
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