BENAZEPRIL HYDROCHLORIDE, (R,R)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H28N2O5.ClH
Molecular Weight	460.95
Optical Activity	( + )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of BENAZEPRIL HYDROCHLORIDE, (R,R)-

Structure Search

SMILES

Cl.CCOC(=O)[C@@H](CCC1=CC=CC=C1)N[C@@H]2CCC3=CC=CC=C3N(CC(O)=O)C2=O

InChI

InChIKey=VPSRQEHTHIMDQM-GZJHNZOKSA-N

InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C24H28N2O5
Molecular Weight	424.4895
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.lgcstandards.com/CN/en/Benazepril-Related-Compound-A/p/USP1048620 | https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019851s042lbl.pdf

Benazepril Related Compound A, it is an Impurity. Benazepril is a prodrug which is metabolized by the liver into its active form benazeprilat via cleavage of the drug's ester group. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. Benazeprilat has much greater ACE inhibitory activity than does Benazepril. It is indicated for the treatment of hypertension.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:40:21 GMT 2025` Edited by `admin` on `Mon Mar 31 21:40:21 GMT 2025`
Record UNII	ZGK2LDW9PT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENAZEPRIL HYDROCHLORIDE, (R,R)-

Common Name

English

BENAZEPRIL RELATED COMPOUND A

Preferred Name

English

Benazepril Related Compound A [USP-RS]

Common Name

English

2-[(R)-3-{[(R)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl]acetic acid hydrochloride

Systematic Name

English

(3R) 3-[[(1R)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid, monohydrochloride

Systematic Name

English

1H-1-BENZAZEPINE-1-ACETIC ACID, 3-(((1R)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)-2,3,4,5-TETRAHYDRO-2-OXO-, MONOHYDROCHLORIDE, (3R)-

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID80175881