BENAZEPRIL HYDROCHLORIDE, (R,R)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H28N2O5.ClH
Molecular Weight	460.95
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of BENAZEPRIL HYDROCHLORIDE, (R,R)-

Structure Search

SMILES

Cl.CCOC(=O)[C@@H](CCC1=CC=CC=C1)N[C@@H]2CCC3=CC=CC=C3N(CC(O)=O)C2=O

InChI

InChIKey=VPSRQEHTHIMDQM-GZJHNZOKSA-N

InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C24H28N2O5
Molecular Weight	424.4895
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.lgcstandards.com/CN/en/Benazepril-Related-Compound-A/p/USP1048620 | https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019851s042lbl.pdfhttps://www.google.com/patents/WO2006084761A1 | https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019851s042lbl.pdf | http://usp35.infostar.com.cn/uspnf/pub/data/v35300/usp35nf30s0_m7495.html

BENAZEPRIL, (±)- is an impurity referred to as Related Compound B, which is a diastereomer of benazepril, an ACE inhibitor, under the brand name Lotensin used primarily in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing the renal and retinal complications of diabetes. BENAZEPRIL, (±)- is used as USP Reference Standard.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Angiotensin-converting enzyme 97 Target ID: CHEMBL1808 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019851s042lbl.pdf \| https://www.ncbi.nlm.nih.gov/pubmed/2999394	Inhibitor 8297		0.1 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019851s042lbl.pdf	Primary		Approved 8429	BENAZEPRIL HYDROCHLORIDE Approved Use Benazepril hydrochloride tablets are indicated for the treatment of hypertension. They may be used alone or in combination with thiazide diuretics. Launch Date 6.777216E11
Unknown 2578

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:09:40 UTC 2023` Edited by `admin` on `Sat Dec 16 07:09:40 UTC 2023`
Record UNII	ZGK2LDW9PT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENAZEPRIL HYDROCHLORIDE, (R,R)-

Common Name

English

((3R)-3-(((1R)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)-2,3,4,5-TETRAHYDRO-2-OXO-1H-1-BENZAZEPINE-1-ACETIC ACID, MONOHYDROCHLORIDE

Common Name

English

1H-1-BENZAZEPINE-1-ACETIC ACID, 3-(((1R)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)-2,3,4,5-TETRAHYDRO-2-OXO-, HYDROCHLORIDE (1:1), (3R)-

Common Name

English

BENAZEPRIL RELATED COMPOUND A [USP IMPURITY]

Common Name

English

1H-1-BENZAZEPINE-1-ACETIC ACID, 3-(((1R)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)-2,3,4,5-TETRAHYDRO-2-OXO-, MONOHYDROCHLORIDE, (3R)-

Common Name

English

BENAZEPRIL RELATED COMPOUND A [USP-RS]

Common Name

English

BENAZEPRIL RELATED COMPOUND A

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID80175881