| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H10O3 |
| Molecular Weight | 238.2381 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC2=C(C=C1)C(=O)C=C(O2)C3=CC=CC=C3
InChI
InChIKey=MQGPSCMMNJKMHQ-UHFFFAOYSA-N
InChI=1S/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H
7-hydroxyflavone belongs to the flavone subgroup of flavonoids. It is a potent inhibitor of 20alpha-hydroxysteroid dehydrogenase (AKR1C1), aromatase (cytochrome P450 19; CYP19), aldo-keto reductases AKR1B10 and AKR1B1. It can inhibit LPS-induced inflammation via attenuating the production of NO, PGE2, TNF-alpha and IL-6, indicating that it may be lead compound for developing anti-inflammatory agent. 7-hydroxyflavone may serve as potential protective agents in the treatment of patients with chronic EV71 infection.
Approval Year
Sample Use Guides
Renal proximal tubule (NRK52E) cells were pre-treated with 20 uM 7-Hydroxyflavone overnight prior to treatment with 200 uM nicotine and cell viability was determined 24 hours later. Nicotine significantly decreases cell viability, which was prevented by pretreatment with 7-Hydroxyflavone.
SUBSTANCE RECORD
