CLOTIAZEPAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H15ClN2OS
Molecular Weight	318.821
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=CC2=C(S1)N(C)C(=O)CN=C2C3=C(Cl)C=CC=C3

InChI

InChIKey=CHBRHODLKOZEPZ-UHFFFAOYSA-N

InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.aemps.gob.es/cima/pdfs/es/p/55479/55479_p.pdf | https://www.ncbi.nlm.nih.gov/pubmed/18604239

Clotiazepam is a compound of the benzodiazepine class. The drug was developed in Japan and approved for the treatment of insomnia, anxiety and before anesthesia. Clotiazepam was marketed worlwide under different names, however, currently it is available only in South America under the name Neuroval and presumably in Japan. Clotiazepam exerts its action by binding and activating GABA-A receptors.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18604239	Agonist 2678		184.0 nM [EC50]

Conditions

Condition	Modality	Highest Phase	Product
Insomnia 108 Sources: https://www.aemps.gob.es/cima/pdfs/es/p/55479/55479_p.pdf	Primary	Approved 8429	DISTENSAN Approved Use Doctors prescribe Distensan for disorders in the sleep rhythm and all forms of insomnia, especially when there are difficulties in falling asleep, either initially or after premature awakening. In most cases only a short-term treatment with Distensan (usually not more than two weeks) is needed. Distensan is also used for the treatment of anxiety, nervous tension, irritability emotional disturbances and before anesthesia (anesthetic premedication).
Anxiety 267 Sources: https://www.aemps.gob.es/cima/pdfs/es/p/55479/55479_p.pdf	Primary	Approved 8429	NEUROVAL Approved Use The treatment of anxiety.
Pain 614 Sources: https://www.aemps.gob.es/cima/pdfs/es/p/55479/55479_p.pdf	Preventing	Approved 8429	DISTENSAN Approved Use Doctors prescribe Distensan for disorders in the sleep rhythm and all forms of insomnia, especially when there are difficulties in falling asleep, either initially or after premature awakening. In most cases only a short-term treatment with Distensan (usually not more than two weeks) is needed. Distensan is also used for the treatment of anxiety, nervous tension, irritability emotional disturbances and before anesthesia (anesthetic premedication).

PubMed

Title	Date	PubMed
Clotiazepam-induced acute hepatitis.	1989 Sep	2572625
Bilateral angle closure glaucoma and visual loss precipitated by antidepressant and antianxiety agents in a patient with depression.	2000 Sep-Oct	10965252
[Who is the underdog? The case of tea producers in Rize].	2001	19714922
[New species and sympatric relations of the chigger mite species group Talmiensis (Trombiculidae, Neotrombicula)].	2001 Nov-Dec	11881135
Clocapramine-related fatality. Postmortem drug levels in multiple psychoactive drug poisoning.	2001 Oct 15	11587865
Isolation, identification and seasonal distribution of soilborne fungi in tea growing areas of Iyidere-Ikizdere vicinity (Rize-Turkey).	2006	16721881
Pharmacological properties of GABAA receptors containing gamma1 subunits.	2006 Feb	16272224
Geo-relationship between cancer cases and the environment by GIS: a case study of Trabzon in Turkey.	2009 Dec	20049256
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443
Molecular evidence for Anaplasma phagocytophilum in Ixodes ricinus from Turkey.	2010 Jan	19744685
The prevalence of nutritional anemia in pregnancy in an east Anatolian province, Turkey.	2010 Jun 10	20537176
Assessment of the impact of altitude on nasal airflow via expiratory nasal sound spectral analysis.	2010 Nov	20401663

Patents

Sample Use Guides

In Vivo Use Guide

Treatment of anxiety: the usual dose in adults is 1 tablet (10 mg) 1 to 3 times a day for 8-12 weeks. Treatment of insomnia: the usual adult dose is 1 tablet (10 mg) to 2 tablets (20 mg) administered at night, before bedtime. The duration of treatment is usually 2-4 weeks.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

CLOTIAZEPAM

Official Name

English

CLOTIAZEPAM [MI]

Common Name

English

CLOTIAZEPAM [MART.]

Common Name

English

Clotiazepam [WHO-DD]

Common Name

English

RIZE

Brand Name

English

5-(O-CHLOROPHENYL)-7-ETHYL-1,3-DIHYDRO-1-METHYL-2H-THIENO(2,3-E)-1,4-DIAZEPIN-2-ONE

Common Name

English

CLOTIAZEPAM [JAN]

Common Name

English

clotiazepam [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012