Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H11N.HI |
| Molecular Weight | 249.0921 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
I.NCCC1=CC=CC=C1
InChI
InChIKey=UPHCENSIMPJEIS-UHFFFAOYSA-N
InChI=1S/C8H11N.HI/c9-7-6-8-4-2-1-3-5-8;/h1-5H,6-7,9H2;1H
β-phenylethylamine (2-phenylethylamine) is a small amine containing alkaloid synonymous with phenethylamine and the acronym PEA; in the human body it has a neuromodulator/neurotransmitter role and is known as a trace amine due to its low quantity relative to other bioactive amino acids. PEA was characterized as a substrate for type B monoamine oxidase. PEA functions by activating trace amine receptors (including TAAR1 and TAAR2) thereby regulating monoamine turnover. Ring-substituted phenethylamines, commonly known as 2Cs, are designer drugs that are emerging as new drugs of abuse. PEA administration may be therapeutic in selected depressed patients.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Following the trace of elusive amines. | 2001 Aug 14 |
|
| Effects of carboxyl-terminal truncations on the activity and solubility of human monoamine oxidase B. | 2001 Aug 3 |
|
| Loss of serotonin oxidation as a component of the altered substrate specificity in the Y444F mutant of recombinant human liver MAO A. | 2001 Dec 11 |
|
| Apomorphine, dopamine and phenylethylamine reduce the proportion of phosphorylated insulin receptor substrate 1. | 2001 Dec 14 |
|
| Biogenic amines in vacuum-packaged and carbon dioxide-controlled atmosphere-packaged fresh pork stored at -1.50 degrees C. | 2001 Feb |
|
| 2-Naphthylamine, a compound found in cigarette smoke, decreases both monoamine oxidase A and B catalytic activity. | 2001 Feb 2 |
|
| Trace amines: identification of a family of mammalian G protein-coupled receptors. | 2001 Jul 31 |
|
| A sensitive method for determining levels of [-]-2,5,-dimethoxy-4-methylamphetamine in the brain tissue. | 2001 Jul-Aug |
|
| Structure-activity studies leading to (-)1-(benzofuran-2-yl)-2-propylaminopentane, ((-)BPAP), a highly potent, selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. | 2001 May |
|
| Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis. | 2001 Nov 27 |
|
| Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. | 2001 Winter |
|
| Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue. | 2002 Aug 1 |
|
| High-performance liquid chromatographic determination of biogenic amines in poultry carcasses. | 2002 Aug 28 |
|
| Analysis of enantiomers of chiral phenethylamine drugs by capillary gas chromatography/mass spectrometry/flame-ionization detection and pre-column chiral derivatization. | 2002 Dec 31 |
|
| Stereospecific cleavage of carbon-phosphorus bonds: stereochemical course of the phosphinoyl curtius (Harger) reaction. | 2002 Feb-Mar |
|
| Do we know the mechanism of chiral recognition between cyclodextrins and analytes? | 2002 Jan 15 |
|
| Characterization of selected Spanish table wine samples according to their biogenic amine content from liquid chromatographic determination. | 2002 Jul 31 |
|
| Application of ligand SAR, receptor modeling and receptor mutagenesis to the discovery and development of a new class of 5-HT(2A) ligands. | 2002 Jun |
|
| [Neuroimaging and neurochemical studies of Rett syndrome]. | 2002 May |
|
| Simultaneous separation of common mono- and divalent cations on a calcinated silica gel column by ion chromatography with indirect photometric detection and aromatic monoamines-oxalic acid, containing crown ethers, used as eluent. | 2002 May 17 |
|
| Degradation of benzyldimethylalkylammonium chloride by Aeromonas hydrophila sp. K. | 2003 |
|
| Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. | 2003 Jan |
Sample Use Guides
Early research shows that taking 10-60 mg of phenethylamine by mouth per day along with 5 mg of the antidepressant selegiline (Anipryl, Eldepryl) twice per day for 4 weeks relieves depression in 60% of people. Of the people who respond to initial treatment with phenethylamine plus selegiline, 86% show continued depression relief when treated for up to 50 weeks.
Excretion study of phenethylamine in man: single oral dose of 300 mg.
Rats: 20, 40, 100 mg/kg ip or 1.0, 2.5, and 5.0 mg/kg iv
Route of Administration:
Other
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
Z8V3FVH6WY
Created by
admin on Sat Dec 16 19:29:12 GMT 2023 , Edited by admin on Sat Dec 16 19:29:12 GMT 2023
|
PRIMARY | |||
|
151059-43-7
Created by
admin on Sat Dec 16 19:29:12 GMT 2023 , Edited by admin on Sat Dec 16 19:29:12 GMT 2023
|
PRIMARY | |||
|
23297368
Created by
admin on Sat Dec 16 19:29:12 GMT 2023 , Edited by admin on Sat Dec 16 19:29:12 GMT 2023
|
PRIMARY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
