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Details

Stereochemistry ACHIRAL
Molecular Formula C18H17F3N2O2
Molecular Weight 350.335
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of J-147

SMILES

COC1=CC=CC(\C=N\N(C(=O)C(F)(F)F)C2=C(C)C=C(C)C=C2)=C1

InChI

InChIKey=HYMZAYGFKNNHDN-SSDVNMTOSA-N
InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+

HIDE SMILES / InChI

Approval Year

Name Type Language
J-147
Code English
ACETIC ACID, 2,2,2-TRIFLUORO-, (2E)-1-(2,4-DIMETHYLPHENYL)-2-((3-METHOXYPHENYL)METHYLENE)HYDRAZIDE
Systematic Name English
ACETIC ACID, 2,2,2-TRIFLUORO-, 1-(2,4-DIMETHYLPHENYL)-2-((3-METHOXYPHENYL)METHYLENE)HYDRAZIDE
Systematic Name English
N-(2,4-DIMETHYLPHENYL)-2,2,2-TRIFLUORO-N-((E)-(3-METHOXYPHENYL)METHYLIDENEAMINO)ACETAMIDE
Systematic Name English
J147
Code English
Code System Code Type Description
CAS
1807913-16-1
Created by admin on Sat Dec 16 01:30:19 GMT 2023 , Edited by admin on Sat Dec 16 01:30:19 GMT 2023
PRIMARY
CAS
1146963-51-0
Created by admin on Sat Dec 16 01:30:19 GMT 2023 , Edited by admin on Sat Dec 16 01:30:19 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY
DRUG BANK
DB13957
Created by admin on Sat Dec 16 01:30:19 GMT 2023 , Edited by admin on Sat Dec 16 01:30:19 GMT 2023
PRIMARY
PUBCHEM
25229652
Created by admin on Sat Dec 16 01:30:19 GMT 2023 , Edited by admin on Sat Dec 16 01:30:19 GMT 2023
PRIMARY
WIKIPEDIA
J147
Created by admin on Sat Dec 16 01:30:19 GMT 2023 , Edited by admin on Sat Dec 16 01:30:19 GMT 2023
PRIMARY J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. The approach that lead to development of the J147 drug was to screen candidate molecules for anti-aging effects, instead of targeting the amyloid plaques. It is contrary to the most of other approaches to develop drugs against the Alzheimer's disease that target the plaque deposits in the brain. The J147 drug is also reported to address other biological aging factors, such as preventing the leakage of blood from microvessels in mice brains.
EC SCIENTIFIC COMMITTEE ON CONSUMER SAFETY OPINION
J147
Created by admin on Sat Dec 16 01:30:19 GMT 2023 , Edited by admin on Sat Dec 16 01:30:19 GMT 2023
PRIMARY
MANUFACTURER PRODUCT INFORMATION
J147
Created by admin on Sat Dec 16 01:30:19 GMT 2023 , Edited by admin on Sat Dec 16 01:30:19 GMT 2023
PRIMARY Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble A.BETA.40 and A.BETA.42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.
FDA UNII
Z41H3C5BT9
Created by admin on Sat Dec 16 01:30:19 GMT 2023 , Edited by admin on Sat Dec 16 01:30:19 GMT 2023
PRIMARY