SPHINGOSINE 1-PHOSPHATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H38NO5P
Molecular Weight	379.4718
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O

InChI

InChIKey=DUYSYHSSBDVJSM-KRWOKUGFSA-N

InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
Sphingosine 1-phosphate receptor 1 7 Target ID: P21453 Gene ID: 1901.0 Gene Symbol: S1PR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/14732717	Agonist 2752	0.4 nM [IC50]
Sphingosine 1-phosphate receptor 2 1 Target ID: O95136 Gene ID: 9294.0 Gene Symbol: S1PR2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/14732717	Agonist 2752	3.8 nM [EC50]
Sphingosine 1-phosphate receptor 3 2 Target ID: Q99500 Gene ID: 1903.0 Gene Symbol: S1PR3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/14732717	Agonist 2752	0.6 nM [EC50]
Sphingosine 1-phosphate receptor 4 2 Target ID: O95977 Gene ID: 8698.0 Gene Symbol: S1PR4 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/14732717	Agonist 2752	67.0 nM [EC50]
Sphingosine 1-phosphate receptor 5 5 Target ID: Q9H228 Gene ID: 53637.0 Gene Symbol: S1PR5 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/14732717	Agonist 2752	0.5 nM [EC50]

PubMed

Title	Date	PubMed
Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.	2011-09	21632869
Sphingosine 1-phosphate and cancer.	2010-07	20555359
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.	2004-04-02	14732717

Name

Type

Language

4-OCTADECENE-1,3-DIOL, 2-AMINO-, 1-(DIHYDROGEN PHOSPHATE), (2S,3R,4E)-

Preferred Name

English

SPHINGOSINE 1-PHOSPHATE

Official Name

English

C18-SPHINGOSINE 1-PHOSPHATE

Common Name

English

D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C68425