PARSALMIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H18N2O2
Molecular Weight	246.3049
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PARSALMIDE

Structure Search

SMILES

CCCCNC(=O)C1=C(OCC#C)C=CC(N)=C1

InChI

InChIKey=DXHYQIJBUNRPJT-UHFFFAOYSA-N

InChI=1S/C14H18N2O2/c1-3-5-8-16-14(17)12-10-11(15)6-7-13(12)18-9-4-2/h2,6-7,10H,3,5,8-9,15H2,1H3,(H,16,17)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67100267 | https://www.drugfuture.com/chemdata/parsalmide.html | https://www.ncbi.nlm.nih.gov/pubmed/11525842

PARSALMIDE, a benzamide derivative, is an anti-inflammatory drug with analgesic effect. It may also possess anxiolytic and tranquilizing properties. PARSALMIDE was commercialized in Italy until 1985 with the brand name of Synovial®, that was widely used to treat arthritic patients.

Approval Year

PubMed

PubMed

Title	Date	PubMed
In vitro mutagenicity of anti-inflammatory parsalmide analogues PA7, PA10, and PA31 triggered by biotransformation into hydroxy derivatives.	2006 Mar	16417948

Patents

Patents

Sample Use Guides

In Vitro Use Guide

Parsalmide inhibited purified ovine COX-1 and COX-2 in vitro with IC50 9.92 uM 155 uM, respectively.

Name

Type

Language

PARSALMIDE

Official Name

English

PARSALMIDE [MART.]

Common Name

English

5-AMINO-N-BUTYL-2-(2-PROPYNYLOXY)BENZAMIDE

Systematic Name

English

PARSALMIDE [MI]

Common Name

English

parsalmide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257

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Code System Code Type Description

DRUG CENTRAL

3418

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NCI_THESAURUS

C66326

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MERCK INDEX

m1220

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Merck Index

EPA CompTox

DTXSID80865553

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ChEMBL

CHEMBL2107094

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EVMPD

SUB09633MIG

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PUBCHEM

72095

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MESH

C100267

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FDA UNII

YQH5093J7C

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ECHA (EC/EINECS)

250-274-2

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CAS

30653-83-9

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INN

3628

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SMS_ID

100000082999

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ACTIVE MOIETY


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