NIDROXYZONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H10N4O5
Molecular Weight	242.1888
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of NIDROXYZONE

Structure Search

SMILES

NC(=O)N(CCO)\N=C\C1=CC=C(O1)[N+]([O-])=O

InChI

InChIKey=FJVAAURIDNIYAE-BJMVGYQFSA-N

InChI=1S/C8H10N4O5/c9-8(14)11(3-4-13)10-5-6-1-2-7(17-6)12(15)16/h1-2,5,13H,3-4H2,(H2,9,14)/b10-5+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15442384 | https://www.ncbi.nlm.nih.gov/pubmed/24542405 | https://www.drugfuture.com/chemdata/nidroxyzone.html

Nidroxyzone (Furadroxyl) is an antibacterial agent. It was used for the treatment of experimental trypanosomiasis in laboratory animals.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
The effect of furadroxyl treatment and x-irradiation on the hyaluronidase concentration of rat testes.	1957-01	13384389
Pyruvate oxidation in testicular tissues during furadroxyl-induced spermatogenic arrest.	1955-06	14391262
The use of 5-nitro-2-furaldehyde-2(2-hydroxyethyl) semicarbazone (furadroxyl) in the treatment of experimental trypanosomiasis in laboratory animals.	1953-04	24542405
[Antibacterial action of neomycin and furadroxyl in vitro and in vivo].	1950-06-26	15442384

Patents

Patents

Name

Type

Language

NSC-6474

Preferred Name

English

NIDROXYZONE

Official Name

English

nidroxyzone [INN]

Common Name

English

5-NITRO-2-FURALDEHYDE 2-(2-HYDROXYETHYL)SEMICARBAZONE

Systematic Name

English

NIDROXYZONE [MI]

Common Name

English

NITROFUROXIZONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394

Created by admin on Wed Apr 02 08:29:45 GMT 2025 , Edited by admin on Wed Apr 02 08:29:45 GMT 2025

Code System Code Type Description

ECHA (EC/EINECS)

206-970-3

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NSC

6474

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SMS_ID

100000084401

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NCI_THESAURUS

C84014

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INN

693

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EVMPD

SUB09252MIG

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CAS

405-22-1

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DRUG CENTRAL

3794

Created by admin on Wed Apr 02 08:29:45 GMT 2025 , Edited by admin on Wed Apr 02 08:29:45 GMT 2025

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FDA UNII

YN9DMN3CVQ

Created by admin on Wed Apr 02 08:29:45 GMT 2025 , Edited by admin on Wed Apr 02 08:29:45 GMT 2025

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EPA CompTox

DTXSID701015578

Created by admin on Wed Apr 02 08:29:45 GMT 2025 , Edited by admin on Wed Apr 02 08:29:45 GMT 2025

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PUBCHEM

9570072

Created by admin on Wed Apr 02 08:29:45 GMT 2025 , Edited by admin on Wed Apr 02 08:29:45 GMT 2025

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ChEMBL

CHEMBL92444

Created by admin on Wed Apr 02 08:29:45 GMT 2025 , Edited by admin on Wed Apr 02 08:29:45 GMT 2025

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MERCK INDEX

m366

Created by admin on Wed Apr 02 08:29:45 GMT 2025 , Edited by admin on Wed Apr 02 08:29:45 GMT 2025

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Merck Index

ACTIVE MOIETY


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