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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H22N2S.ClH
Molecular Weight 334.907
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRIMEPRAZINE HYDROCHLORIDE, (R)-

SMILES

Cl.C[C@H](CN(C)C)CN1C2=CC=CC=C2SC3=C1C=CC=C3

InChI

InChIKey=QUVSTPKPFAPBQU-PFEQFJNWSA-N
InChI=1S/C18H22N2S.ClH/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20;/h4-11,14H,12-13H2,1-3H3;1H/t14-;/m1./s1

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
[Inactivation of Trypanosoma cruzi trypanothione reductase by phenothiazine cationic free radicals].
2001 Jan-Mar
Myeloperoxidase-generated phenothiazine cation radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase.
2002 Apr-Jun
Antihistamines in the treatment of dermatitis.
2003 Nov-Dec
Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study.
2004 Dec
Reversal of an antihistamine-induced coma with flumazenil.
2004 May
[Prescription of psychotropic drugs in paediatry: approved indications and therapeutic perspectives].
2005 Jul-Aug
[Methadone and sleep apnea syndrome].
2005 Mar
Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex.
2005 May
Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation.
2005 May
Mucosal delivery of cytotoxic therapeutic agents: response of rat nasal mucosa to microencapsulated ethopropazine HCl enantiomer.
2005 Nov
Effectiveness of alimemazine in controlling retching after Nissen fundoplication.
2005 Nov
A comparative study on the effects of oral amiodarone and trimeprazine, two in vitro retinyl ester hydrolase inhibitors, on the metabolic availability of vitamin A in rats.
2005 Nov
Preliminary studies on phenothiazine-mediated reversal of multidrug resistance in mouse lymphoma and COLO 320 cells.
2005 Nov-Dec
Enantioseparation of phenothiazines in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors.
2005 Oct
Determination of trimeprazine-facilitated sedation in children by hair analysis.
2006 Jul-Aug
A cluster-randomized educational intervention to reduce inappropriate prescription patterns for elderly patients in general practice--The Prescription Peer Academic Detailing (Rx-PAD) study [NCT00281450].
2006 Jun 11
Behavioral treatment of bedtime problems and night wakings in infants and young children.
2006 Oct
Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants.
2006 Sep
Drop-to-drop solvent microextraction coupled with gas chromatography/mass spectrometry for rapid determination of trimeprazine in urine and blood of rats: application to pharmacokinetic studies.
2007
Large-scale identification of human genes implicated in epidermal barrier function.
2007
Evaluation of enantioselective binding of basic drugs to plasma by ACE.
2007 Aug
Effects of fibroblasts and microenvironment on epidermal regeneration and tissue function in long-term skin equivalents.
2007 Dec
Enantioseparation of phenotiazines by affinity electrokinetic chromatography using human serum albumin as chiral selector: application to enantiomeric quality control in pharmaceutical formulations.
2007 Jan 23
Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes.
2007 Jun 22
Enantioseparation of phenothiazines in CD-modified CZE using single isomer sulfated CD as a chiral selector.
2007 Nov
Quetiapine and drug interactions: evidence from a routine therapeutic drug monitoring service.
2007 Oct
The pK(a) Distribution of Drugs: Application to Drug Discovery.
2007 Sep 17
[Alimemazine in medical practice].
2008
A fixed dilated pupil: Pilocarpine: better than a scan.
2008 Jan 26
Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.
2008 May 1
Simultaneous determination of some phenothiazine derivatives in human blood by headspace solid-phase microextraction and gas chromatography with nitrogen-phosphorus detection.
2008 Nov-Dec
[Is alimemazine a suitable sleeping agent for children?].
2008 Oct 9
Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole.
2009 Apr
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.
2009 Jul 14
Development of an ichthyosiform phenotype in Alox12b-deficient mouse skin transplants.
2009 Jun
Management of pain in children with burns.
2010
Development of a universal psycho-educational intervention to prevent common postpartum mental disorders in primiparous women: a multiple method approach.
2010 Aug 18
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Significance of S100A2 and S100A4 Expression in the Progression of Prostate Adenocarcinoma.
2010 Jul
Review of therapeutic agents for burns pruritus and protocols for management in adult and paediatric patients using the GRADE classification.
2010 Sep
Large-scale proteomic identification of S100 proteins in breast cancer tissues.
2010 Sep 3
Patents
Name Type Language
TRIMEPRAZINE HYDROCHLORIDE, (R)-
Common Name English
10H-PHENOTHIAZINE-10-PROPANAMINE, N,N,.BETA.-TRIMETHYL-, HYDROCHLORIDE (1:1), (R)-
Systematic Name English
ALIMEMAZINE HYDROCHLORIDE, (R)-
Common Name English
Code System Code Type Description
PUBCHEM
76965887
Created by admin on Sat Dec 16 05:14:43 GMT 2023 , Edited by admin on Sat Dec 16 05:14:43 GMT 2023
PRIMARY
FDA UNII
YKL63XT90B
Created by admin on Sat Dec 16 05:14:43 GMT 2023 , Edited by admin on Sat Dec 16 05:14:43 GMT 2023
PRIMARY