LOTEPREDNOL ETABONATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H31ClO7
Molecular Weight	466.952
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](OC(=O)OCC)(C(=O)OCCl)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=DMKSVUSAATWOCU-HROMYWEYSA-N

InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1

HIDE SMILES / InChI

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
621 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/25134493	0.5 μg single, intraocular dose: 0.5 μg route of administration: Intraocular experiment type: SINGLE co-administered:		LOTEPREDNOL cornea	Oryctolagus cuniculus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
1130 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/25134493	0.5 μg single, intraocular dose: 0.5 μg route of administration: Intraocular experiment type: SINGLE co-administered:		LOTEPREDNOL cornea	Oryctolagus cuniculus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
3.75 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/25134493	0.5 μg single, intraocular dose: 0.5 μg route of administration: Intraocular experiment type: SINGLE co-administered:		LOTEPREDNOL cornea	Oryctolagus cuniculus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
2% EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/28017774			LOTEPREDNOL plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
1 drop 4 times / day multiple, topical Recommended Dose: 1 drop, 4 times / day Route: topical Route: multiple Dose: 1 drop, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/9124242 Page: p.461	unhealthy, 3.4 ± 1.1 n = 109 Health Status: unhealthy Condition: Giant papillary conjunctivitis Age Group: 3.4 ± 1.1 Sex: M+F Population Size: 109 Sources: https://pubmed.ncbi.nlm.nih.gov/9124242 Page: p.461	Disc. AE: Intraocular pressure increased... AEs leading to discontinuation/dose reduction: Intraocular pressure increased (2.8%) Sources: https://pubmed.ncbi.nlm.nih.gov/9124242 Page: p.461

AEs

AE	Significance	Dose	Population
Intraocular pressure increased	2.8% Disc. AE	1 drop 4 times / day multiple, topical Recommended Dose: 1 drop, 4 times / day Route: topical Route: multiple Dose: 1 drop, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/9124242 Page: p.461	unhealthy, 3.4 ± 1.1 n = 109 Health Status: unhealthy Condition: Giant papillary conjunctivitis Age Group: 3.4 ± 1.1 Sex: M+F Population Size: 109 Sources: https://pubmed.ncbi.nlm.nih.gov/9124242 Page: p.461

Name

Type

Language

LOTEPREDNOL ETABONATE

Official Name

English

ZYLET COMPONENT LOTEPREDNOL ETABONATE

Common Name

English

Chloromethyl 11β,17-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylate, 17-(ethyl carbonate)

Common Name

English

P-5604

Code

English

LOTEPREDNOL ETABONATE [VANDF]

Common Name

English

LOTEPREDNOL ETABONATE [USAN]

Common Name

English

CDDD5604

Code

English

HGP-1

Code

English

Loteprednol etabonate [WHO-DD]

Common Name

English

EYSUVIS

Brand Name

English

ALREX

Brand Name

English

LOTEPREDNOL ETABONATE [MART.]

Common Name

English

ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID, 17-((ETHOXYCARBONYL)OXY)-11-HYDROXY-3-OXO-, CHLOROMETHYL ESTER, (11.BETA.,17.ALPHA.)-

Systematic Name

English

LOTEPREDNOL ETABONATE [JAN]

Common Name

English

INVELTYS

Brand Name

English

CDDD-5604

Code

English

LOTEMAX

Brand Name

English

KPI-121

Code

English

LOTEPREDNOL ETABONATE [MI]

Common Name

English

LOTEPREDNOL ETABONATE COMPONENT OF ZYLET

Common Name

English

LOTEPREDNOL ETABONATE [ORANGE BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521