LIFIBRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H21Cl2NO4
Molecular Weight	410.291
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC(CC1)OC(=O)C(OC2=CC=C(Cl)C=C2)OC3=CC=C(Cl)C=C3

InChI

InChIKey=QDGIAPPCJRFVEK-UHFFFAOYSA-N

InChI=1S/C20H21Cl2NO4/c1-23-12-10-18(11-13-23)25-19(24)20(26-16-6-2-14(21)3-7-16)27-17-8-4-15(22)5-9-17/h2-9,18,20H,10-13H2,1H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1135523 | https://www.ncbi.nlm.nih.gov/pubmed/5811622 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 732, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Lifibrate is the antihyperlipidemic agent. It is a potent hepatic peroxisome proliferator. Administration of lifibrate at a dietary concentration of 0.15% for 3 weeks, increased the activity of catalase in both liver and kidney of male wild type (Cs-a strain) mice. The hypolipidemic activity of lifibrate is eight to nine times greater than that of chlorphenoxy isobutyric acid ethyl ester in the male Wistar rat.

Approval Year

PubMed

Title	Date	PubMed
Hypolipidemic drugs are inhibitors of phosphatidylcholine synthesis.	1982 Nov	6294663
Phosphoglyceride biosynthesis by brain microsomes: centrophenoxine, SaH-42-348, and DH-990 inhibit phospholipid N-methylation.	1984 Nov 15	6437335

Name

Type

Language

LIFIBRATE

Official Name

English

42-348

Code

English

lifibrate [INN]

Common Name

English

LIFIBRATE [USAN]

Common Name

English

ACETIC ACID, BIS(4-CHLOROPHENOXY)-, 1-METHYL-4-PIPERIDINYL ESTER

Common Name

English

1-METHYL-4-PIPERIDYL GLYOXYLATE 2-(BIS(P-CHLOROPHENYL) ACETAL)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98150