Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H21Cl2NO4 |
| Molecular Weight | 410.291 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCC(CC1)OC(=O)C(OC2=CC=C(Cl)C=C2)OC3=CC=C(Cl)C=C3
InChI
InChIKey=QDGIAPPCJRFVEK-UHFFFAOYSA-N
InChI=1S/C20H21Cl2NO4/c1-23-12-10-18(11-13-23)25-19(24)20(26-16-6-2-14(21)3-7-16)27-17-8-4-15(22)5-9-17/h2-9,18,20H,10-13H2,1H3
Lifibrate is the antihyperlipidemic agent. It is a potent hepatic peroxisome proliferator. Administration of lifibrate at a dietary concentration of 0.15% for 3 weeks, increased the activity of catalase in both liver and kidney of male wild type (Cs-a strain) mice. The hypolipidemic activity of lifibrate is eight to nine times greater than that of chlorphenoxy isobutyric acid ethyl ester in the male Wistar rat.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Phosphoglyceride biosynthesis by brain microsomes: centrophenoxine, SaH-42-348, and DH-990 inhibit phospholipid N-methylation. | 1984-11-15 |
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| Hypolipidemic drugs are inhibitors of phosphatidylcholine synthesis. | 1982-11 |
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| Hypolipidemic activity of in vitro inhibitors of hepatic and intestinal sn-glycerol-3-phosphate acyltransferase and phosphatidate phosphohydrolase. | 1977-06 |
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| Morphometric analysis of the ultrastructural changes in rat liver induced by the peroxisome proliferator SaH 42-348. | 1976-12 |
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| 1-methyl-4piperidyl-bis (P-chlorophenoxy) acetate: a new hypolipidemic peroxisome proliferator. | 1975-03 |
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| Effect of SaH 42-348, an analog of clofibrate, on lipid metabolism in rats. | 1973-06 |
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| Laboratory studies of 1-methyl-4-piperidyl bis(p-chlorophenoxy) acetate (SaH 42-348)--a new hypolipidemic agent. | 1969-08 |
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C98150
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CHEMBL1883563
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Y4X961F8Z1
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100000082312
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244-839-2
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22204-91-7
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C100041
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C82243
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SUB08511MIG
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DTXSID1046217
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3473
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31060
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ACTIVE MOIETY
