MATAIRESINOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H22O6
Molecular Weight	358.3851
Optical Activity	( - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=C(O)C=CC(C[C@H]2COC(=O)[C@@H]2CC3=CC(OC)=C(O)C=C3)=C1

InChI

InChIKey=MATGKVZWFZHCLI-LSDHHAIUSA-N

InChI=1S/C20H22O6/c1-24-18-9-12(3-5-16(18)21)7-14-11-26-20(23)15(14)8-13-4-6-17(22)19(10-13)25-2/h3-6,9-10,14-15,21-22H,7-8,11H2,1-2H3/t14-,15+/m0/s1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
inflammatory response 47	Inhibitor 8,504
reactive oxygen species metabolic process 68	Modulator 846
Casein kinase I, rat 1	Inhibitor 8,504	10.0 µM [IC50]
nitric oxide biosynthetic process 17	Inhibitor 8,504	11.5 µM [IC50]
IL-6/STAT3 pathway 1	Inhibitor 8,504	2.92 µM [IC50]

PubMed

PubMed

Show entries

Title	Date	PubMed
Characterization of (-)-matairesinol as a potent inhibitor of casein kinase I in vitro.	2003 Mar	12612451
Anti-osteoclastogenic activity of matairesinol via suppression of p38/ERK-NFATc1 signaling axis.	2014 Jan 21	24444335

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Name

Type

Language

MATAIRESINOL

Official Name

English

FEMA NO. 4762

Preferred Name

English

(-)-MATAIRESINOL

Common Name

English

2(3H)-FURANONE, DIHYDRO-3,4-BIS((4-HYDROXY-3-METHOXYPHENYL)METHYL)-, (3R,4R)-

Systematic Name

English

(8R,8'R)-(-)-MATAIRESINOL

Common Name

English

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Classification Tree

Code System

Code

Dietary Fiber

NCI_THESAURUS

C63638

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Code System

Code

Type

Description

DRUG BANK

DB04200

PRIMARY

JECFA MONOGRAPH

2183

PRIMARY

CHEBI

6698

PRIMARY

WIKIPEDIA

Matairesinol

PRIMARY

EPA CompTox

DTXSID40920490

PRIMARY

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ACTIVE MOIETY


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MATAIRESINOL