MATAIRESINOL

[H][C@]2(CC1=CC=C(O)C(OC)=C1)COC(=O)[C@]2([H])CC3=CC(OC)=C(O)C=C3

InChIKey=MATGKVZWFZHCLI-LSDHHAIUSA-N

InChI=1S/C20H22O6/c1-24-18-9-12(3-5-16(18)21)7-14-11-26-20(23)15(14)8-13-4-6-17(22)19(10-13)25-2/h3-6,9-10,14-15,21-22H,7-8,11H2,1-2H3/t14-,15+/m0/s1

Targets

Primary Target	Pharmacology	Potency
inflammatory response 47 Target ID: GO:0006954 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28512713	Inhibitor 8297
reactive oxygen species metabolic process 68 Target ID: GO:0072593 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22483751	Modulator 828
Casein kinase I, rat 1 Target ID: Casein kinase I, rat Sources: https://www.ncbi.nlm.nih.gov/pubmed/12612451	Inhibitor 8297	10.0 µM [IC50]
nitric oxide biosynthetic process 17 Target ID: GO:0006809 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27774796	Inhibitor 8297	11.5 µM [IC50]
IL-6/STAT3 pathway 1 Target ID: IL-6/STAT3 pathway Sources: https://www.ncbi.nlm.nih.gov/pubmed/25100250	Inhibitor 8297	2.92 µM [IC50]

PubMed

Title	Date	PubMed
Anti-osteoclastogenic activity of matairesinol via suppression of p38/ERK-NFATc1 signaling axis.	2014 Jan 21	24444335
Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model.	2016 Jul 1	27085937
Matairesinol Suppresses Neuroinflammation and Migration Associated with Src and ERK1/2-NF-κB Pathway in Activating BV2 Microglia.	2017 Oct	28512713

Name

Type

Language

MATAIRESINOL

Official Name

English

(-)-MATAIRESINOL

Common Name

English

FEMA NO. 4762

Code

English

2(3H)-FURANONE, DIHYDRO-3,4-BIS((4-HYDROXY-3-METHOXYPHENYL)METHYL)-, (3R,4R)-

Systematic Name

English

(8R,8'R)-(-)-MATAIRESINOL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C63638