ASPIRIN LYSINE

US Approved OTC

First marketed in 1899

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H8O4.C6H14N2O2
Molecular Weight	326.345
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCCC[C@H](N)C(O)=O.CC(=O)OC1=C(C=CC=C1)C(O)=O

InChI

InChIKey=JJBCTCGUOQYZHK-ZSCHJXSPSA-N

InChI=1S/C9H8O4.C6H14N2O2/c1-6(10)13-8-5-3-2-4-7(8)9(11)12;7-4-2-1-3-5(8)6(9)10/h2-5H,1H3,(H,11,12);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1

HIDE SMILES / InChI

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/011483s029lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/11723249

Aspirin is a nonsteroidal anti-inflammatory drug. Aspirin is unique in this class of drugs because it irreversibly inhibits both COX-1 and COX-2 activity by acetylating a serine residue (Ser529 and Ser516, respectively) positioned in the arachidonic acid-binding channel, thus inhibiting the synthesis of prostaglandins and reducing the inflammatory response. The drug is used either alone or in combination with other compounds for the treatment of pain, headache, as well as for reducing the risk of stroke and heart attacks in patients with brain ischemia and cardiovascular diseases.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 1 30 Target ID: P23219\|\|\|Q5T7T7 Gene ID: 5742.0 Gene Symbol: PTGS1 Target Organism: Homo sapiens (Human) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/200671s000lbl.pdf	Inhibitor 8146		1.2 µM [IC50]
Prostaglandin G/H synthase 2 47 Target ID: P35354 Gene ID: 5743.0 Gene Symbol: PTGS2 Target Organism: Homo sapiens (Human) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/011483s029lbl.pdf	Inhibitor 8146		5.2 µM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Pain 607 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/011483s029lbl.pdf	Primary	Approved 8307	SYNALGOS-DC Approved Use SYNALGOS-DC is a combination of dihydrocodeine, an opioid agonist, aspirin, a nonsteroidal anti-inflammatory drug, and caffeine, a methylxanthine, and is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Launch Date -3.62620813E11
Headache 47 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a00c6776-e9ef-411b-9396-915c3787559a	Primary	Approved 8307	FIORINAL Approved Use FIORINAL is indicated for the relief of the symptom complex of tension (or muscle contraction) headache. Evidence supporting the efficacy and safety of Fiorinal in the treatment of multiple recurrent headaches is unavailable. Caution in this regard is required because butalbital is habit-forming and potentially abusable. Launch Date 2.00016003E11
Myocardial infarction 103 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/200671s000lbl.pdf	Preventing	Approved 8307	DURLAZA Approved Use DURLAZA is a nonsteroidal anti-inflammatory drug indicated to reduce the risk of death and myocardial infarction (MI) in patients with chronic coronary artery disease, such as patients with a history of MI or unstable angina pectoris or with chronic stable angina and to reduce the risk of death and recurrent stroke in patients who have had an ischemic stroke or transient ischemic attack. Launch Date 1.44132486E12
Stroke 143 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/20884_AGGRENOX_prntlbl.pdf	Preventing	Approved 8307	AGGRENOX Approved Use AGGRENOX is indicated to reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis. Launch Date 9.4322878E11

C_max

Value	Dose	Co-administered	Analyte	Population
54.25 mg/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
4.84 mg/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
10.31 mg × h/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
5.12 mg × h/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
0.322 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
0.422 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
68% REVIEW https://www.ncbi.nlm.nih.gov/pubmed/30115648			ASPIRIN plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1670 inducer 753	substrate 985	substrate 1168 inducer 97

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OAT3 625	CYP1A2 1013 CYP2A6 510 CYP2B6 648 CYP2C8 670 CYP2C19 955 CYP2E1 633 esterase 68 UGT1A1 417 UGT1A3 421 UGT1A6 306 UGT1A7 235 UGT1A8 282 UGT1A9 378 UGT1A10 289 UGT2B4 248 UGT2B7 387 P-gp 1491	CYP2C19 283 CYP1A2 671 CYP2E1 121 ABCA1 18 P-gp 252

Drug as perpetrator

Target	Modality	Activity
CYP1A2 1620	inducer 1515 Sources: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1067/mcp.2003.14 Page: -	no
CYP2D6 1826	inducer 1515 Sources: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1067/mcp.2003.14 Page: -	no
CYP2E1 929	inducer 1515 Sources: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1067/mcp.2003.14 Page: -	no
ABCA1 18	inducer 1515 Sources: https://www.karger.com/Article/Abstract/321727 Page: -	yes
CYP2C19 1484	inducer 1515 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes
CYP3A4 1857	inducer 1515 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes
OAT3 627	inhibitor 3185 Sources: https://dmd.aspetjournals.org/content/42/6/996.short Page: -	yes
P-gp 1588	inducer 1515 Sources: https://pubmed.ncbi.nlm.nih.gov/11205285/ Page: -	yes

Drug as victim

Target	Modality	Activity	Metabolite
CYP1A2 1013	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP1A2 1013	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no	salicylic acid 18
CYP2A6 510	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2B6 648	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2B6 648	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no	salicylic acid 18
CYP2C19 955	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2C8 670	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2C9 985	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2D6 1168	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP3A4 1670	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
P-gp 1491	substrate 3264 Sources: https://www.tandfonline.com/doi/full/10.1080/00498254.2020.1757785 Page: -	no
UGT1A8 282	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	no	salicylic acid 18
UGT2B4 248	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	no	salicylic acid 18
UGT2B7 387	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 1242 uM]	salicylic acid 18
UGT1A3 421	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 2337 uM]	salicylic acid 18
UGT1A7 235	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 278.6 uM]	salicylic acid 18
UGT1A6 306	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 40.7 uM]	salicylic acid 18
UGT1A1 417	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 683.1 uM]	salicylic acid 18
UGT1A10 289	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 698.2 uM]	salicylic acid 18
UGT1A9 378	substrate 3264 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 94.2 uM]	salicylic acid 18
CYP2A6 510	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2C19 955	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2C8 670	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2C9 985	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2D6 1168	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2E1 633	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP3A4 1670	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
esterase 68	substrate 3264 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B1-00059	http://www.3bsc.com/index/pro_info.php?id=20271
AA Blocks	AA00I8UA	http://www.aablocks.com/goods/Goods/detail?id=AA00I8UA
AK Scientific, Inc. (AKSCI)	H740	http://www.aksci.com/item_detail.php?cat=H740
Aaron Chemicals	AR00I9M2	http://www.aaronchem.com/50-78-2
AbMole Bioscience	M5426	http://www.abmole.com/products/aspirin.html
Acadechem	ACDS-070196	http://www.acadechemical.com/product/144895
Achemica	ACMC-209kpz	http://www.achemica.com/prodinfo/?id=128318
Achemo Scientific Limited	AC-24217	http://www.achemo.com/search/?Keyword=50-78-2
Achemtek	0104-001327	http://www.achemtek.com/50-78-2
Acros Organics	AC158180500	https://www.fishersci.com/shop/products/acetylsalicylic-acid-99-acros-organics-1/AC158180500
Acros Organics	AC158185000	https://www.fishersci.com/shop/products/acetylsalicylic-acid-99-acros-organics-1/AC158185000
Acros Organics	AC158180025	https://www.fishersci.com/shop/products/acetylsalicylic-acid-99-acros-organics/AC158180025
Alfa Aesar	A12488	https://www.alfa.com/en/catalog/A12488/
Ambinter	Amb17757514	http://www.ambinter.com/reference/17757514
Angene	AGN-PC-0WACEM	http://www.angenechemical.com/productshow/AGN-PC-0WACEM.html
Anward	ANW-31125	http://www.anward.com/pro_result/20981
ApexBio Technology	A4013	http://www.apexbt.com/aspirin-acetylsalicylic-acid.html
Aurora Fine Chemicals LLC	A00.156.463	http://online.aurorafinechemicals.com/info?ID=A00.156.463
Aurora Fine Chemicals LLC	K00.801.915	http://online.aurorafinechemicals.com/info?ID=K00.801.915
Avantor Inc	TCA2262-25G	https://us.vwr.com/store/product/9983116/o-acetylsalicylic-acid-98-0-by-gc-titration-analysis
BOC Sciences	1173022-25-7	https://isotope.bocsci.com/product/acetylsalicylic-acid-13c-cas-1173022-25-7-343874.html
BOC Sciences	97781-16-3	https://www.bocsci.com/2-acetoxybenzoic-3-4-5-6-d4-acid-cas-97781-16-3-item-212339.html
BOC Sciences	921943-73-9	https://www.bocsci.com/acetylsalicylic-acid-d3-cas-921943-73-9-item-466862.html
BioChemPartner	BCP21790	http://www.biochempartner.com/50-78-2-BCP21790
BioCrick	BCC2097	http://www.biocrick.com/Aspirin-Acetylsalicylic-acid-BCC2097.html
Boerchem	BC221833	http://www.boerchem.com/?product_37473.html
Capot Chemical	20190	http://www.capotchem.com/en/20190.htm
Capot Chemical	PubChem20190	http://www.capotchem.com/en/20190.htm
Chem Scene	CS-2001	http://www.chemscene.com/50-78-2.html
ChemMol	49417180	http://www.chemmol.com/chemmol/49417180.html
ChemMol	99097732	http://www.chemmol.com/chemmol/99097732.html
Chemspace	CSSB00000210466	https://chem-space.com/CSSB00000210466
Clearsynth	CS-EG-00025	https://www.clearsynth.com/en/CSEG00025.html
Clearsynth	CS-ER-02340	https://www.clearsynth.com/en/CSER02340.html
Clearsynth	CS-T-01103	https://www.clearsynth.com/en/CST01103.html
Clearsynth	CS-T-47333	https://www.clearsynth.com/en/CST47333.html
DC Chemicals	DC8956	http://www.dcchemicals.com/product_show-Acetylsalicylic_acid.html
Debye Scientific	DS-017139	http://www.debyesci.com/cas_59096-14-9.html
Enamine	Z234893989	https://www.enaminestore.com/catalog/Z234893989
Finetech	FT-0655181	http://www.finetechnology-ind.com/prod/detail/pub/50-78-2.html
Finetech	FT-0661360	http://www.finetechnology-ind.com/prod/detail/pub/97781-16-3.html
Glentham Life Sciences	GL0865	http://www.glentham.com/products/product/GL0865/
Hairui	HR138909	http://www.hairuichem.com/en/product/50-78-2.html
LGC Standards	DRE-C10024000	https://www.lgcstandards.com/US/en/p/DRE-C10024000
LGC Standards	LGCAMP0133.00-11	https://www.lgcstandards.com/US/en/p/LGCAMP0133.00-11
LGC Standards	LGCFOR0133.00	https://www.lgcstandards.com/US/en/p/LGCFOR0133.00
LGC Standards	MM0133.00-0250	https://www.lgcstandards.com/US/en/p/MM0133.00-0250
Lab Network	LN00223310	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00223310
Matrix Scientific	134531	https://www.matrixscientific.com/134531.html
MedChem Express	HY-14654	https://www.medchemexpress.com/aspirin.html
MuseChem	A000653	https://www.musechem.com/product/A000653.html
Oakwood	101923	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=130521&ExtHyperLink=1
Parchem	30462	http://www.parchem.com/chemical-supplier-distributor/Aspirin-USP-2080B--020462.aspx
Parchem	12326	http://www.parchem.com/chemical-supplier-distributor/Aspirin-USP-26-002326.aspx
Parchem	30461	http://www.parchem.com/chemical-supplier-distributor/Aspirin-USP-3080--020461.aspx
Selleck Chemicals	S3017	http://www.selleckchem.com/products/aspirin-acetylsalicylic-acid.html
Sigma-Aldrich	239631_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/239631?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A0200000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/a0200000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A2093_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/a2093?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A3160_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/a3160?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1044006_USP	https://www.sigmaaldrich.com/catalog/product/usp/1044006?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S054539	http://www.sinfoobiotech.com/product/1057937
Smolecule	S519564	http://www.smolecule.com/products/s519564
Synthetic Heterocycles	AFA100669	http://www.synhet.com/products/AFA100669
TCI (Tokyo Chemical Industry)	A2262	http://www.tcichemicals.com/eshop/en/us/commodity/A2262/index.html
THE BioTek	bt-260267	https://www.thebiotek.com/product/inhibitors/bt-260267
Tocris	4092	https://www.tocris.com/products/aspirin_4092
Vitas-M Laboratory	BBL005469	http://www.request.vitasmlab.biz/index.php?option=com_search_stk&Itemid=22&stk=BBL005469&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
VladaChem	VL271248-100G	https://www.vladachem.com/product.php?products=50-78-2
Yuhao Chemical	RT12808	http://www.chemyuhao.com/50-78-2.html
abcr GmbH	AB113303	http://www.abcr.com/shop/en/AB113303
eNovation Chemicals	D408997	http://www.enovationchem.com/productDetails.asp?productID=D408997
iChemical	EBD47326	http://www.ichemical.com/products/50-78-2.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-3199019536	https://mcule.com/MCULE-3199019536/

PubMed

Title	Date	PubMed
Letter: Aspirin sensitivity: other drugs.	1975 Feb	1115460
[Salicylism and glaucoma: reciprocal augmentation of the toxicity of acetazolamide and acetylsalicylic acid].	1999 Feb	10221197
Seizures induced by NSAID.	1999 Jan	10195372
Aspirin and heparin in acute ischaemic stroke in older patients.	1999 Jul	10459730
Increased risk of intracranial hemorrhage when aspirin is combined with warfarin: A meta-analysis and hypothesis.	1999 Jul-Aug	10393408
Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human platelet aggregation.	1999 Mar	10193204
NSAID-induced bronchospasm--a common and serious problem. A report from MEDSAFE, the New Zealand Medicines and Medical Devices Safety Authority.	1999 Sep	10561993
Prospective study of aspirin use and risk of stroke in women.	1999 Sep	10471421
Hypophysectomy and/or peroxisome proliferators strongly influence the levels of phase II xenobiotic metabolizing enzymes in rat testis.	1999 Sep 30	10528994
Leukotriene receptor antagonists may prevent NSAID-induced exacerbations in patients with chronic urticaria.	2000 Aug	10982225
Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.	2000 Dec 8	10993886
Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal anti-inflammatory drugs.	2000 Feb 15	10706128
[Cholestatic hepatitis as a rare side effect of therapy with ticlopidine].	2000 Jul	10965556
An uncommon case of fluid retention simulating a congestive heart failure after aspirin consumption.	2000 Jul	10910377
Indications for early aspirin use in acute ischemic stroke : A combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groups.	2000 Jun	10835439
Aspirin-associated intracerebral hemorrhage: clinical and radiologic features.	2000 Jun 27	10881256
Randomized comparative trial of triflusal and aspirin following acute myocardial infarction.	2000 Mar	10681486
[Aspirin-induced angioedema of the nape of the neck with naproxen cross-reaction: a case report].	2000 May	10896977
Novel platelet inhibitors.	2001	11160773
Collagen as a model system to investigate the use of aspirin as an inhibitor of protein glycation and crosslinking.	2001 Apr	11006510
Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions.	2001 Feb	11161072
The effects of diaspirin cross-linked hemoglobin on the tone of human saphenous vein.	2001 Feb	11159224
Renal function and intensive lowering of blood pressure in hypertensive participants of the hypertension optimal treatment (HOT) study.	2001 Feb	11158211
Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II).	2001 Feb	11157179
Use of aspirin, epistaxis, and untreated hypertension as risk factors for primary intracerebral hemorrhage in middle-aged and elderly people.	2001 Feb	11157173
Systematic review of long term anticoagulation or antiplatelet treatment in patients with non-rheumatic atrial fibrillation.	2001 Feb 10	11159653
Addition of hydrophilic and lipophilic compounds of biological relevance to the monoolein/water system. I. Phase behavior.	2001 Jan	11163344
Antithrombotic agents in coronary artery disease.	2001 Jan	11157652
Antithrombotic therapy in patients with mechanical and biological prosthetic heart valves.	2001 Jan	11157651
Antithrombotic therapy in atrial fibrillation.	2001 Jan	11157649
Use of antithrombotic agents during pregnancy.	2001 Jan	11157646
Platelet-active drugs : the relationships among dose, effectiveness, and side effects.	2001 Jan	11157642
Gastric mucosal resistance to acute injury in experimental portal hypertension.	2001 Jan	11156591
Multiple endothelial injury in epicardial coronary artery induces downstream microvascular spasm as well as remodeling partly via thromboxane A2.	2001 Jan	11153757
Lp(a) lipoprotein--an independent risk factor for coronary heart disease after menopause.	2001 Jan	11153187
The PlA polymorphism of glycoprotein IIIa functions as a modifier for the effect of estrogen on platelet aggregation.	2001 Jan	11151063
Endogenous nitric oxide and prostaglandins synergistically counteract thromboembolism in arterioles but not in venules.	2001 Jan	11145949
Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses.	2001 Jan	11141472
Anticoagulation and heart failure.	2001 Jan	11139802
Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs.	2001 Jan	11138826
Diabetes mellitus with left transverse sinus thrombosis and right transverse sinus aplasia.	2001 Jan	11137180
Review article: the gastrointestinal safety profile of rofecoxib, a highly selective inhibitor of cyclooxygenase-2, in humans.	2001 Jan	11136272
Prevention of pre-eclampsia: status and perspectives 2000.	2001 Jan	11134820
Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid.	2001 Jan	11133261
Increased platelet reactivity and significant changes in coagulation markers after cavopulmonary connection.	2001 Jan	11119465
Low-grade exercise enhances platelet aggregability in patients with obstructive coronary disease independently of myocardial ischemia.	2001 Jan 1	11137827
Blood donations and risk of coronary heart disease in men.	2001 Jan 2	11136685
Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery.	2001 Jan 23	11157686
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.	2001 Jan 5	11137875
Drug Points: tachycardia associated with moxifloxacin.	2001 Jan 6	11141146

Patents

Sample Use Guides

In Vivo Use Guide

Severe pain: Initiate treatment with two capsules (1 capsule contains 16 mg dihydrocodeine bitartrate, 356.4 mg aspirin, and 30 mg caffeine) orally every 4 hours as needed for pain. Headache: One or 2 capsules (1 capsule contains 50 mg butalbital, 325 mg aspirin and 40 mg caffeine) every 4 hours. Total daily dose should not exceed 6 capsules. Prevention of stoke and heart attacks: the recommended dose is one capsule of aspirin (162.5 mg) once daily. Take the capsules with a full glass of water at the same time each day. Prevention of stroke (in combination with dipyridamole): the recommended dose is one capsule (200 mg dipyridamole and 25 mg aspirin) given orally twice daily.

Route of Administration: Enteral

In Vitro Use Guide

Human platelet-rich plasma was incubated with various aspirin concentrations (10, 20, 50, 100, 200, 300, 400, 500 uM) at 37C for up to 4.5 h. Platelet aggregation and thromboxane generation were measured. Inhibition of platelet aggregation and thromboxane formation by 10 uM aspirin was maximal by 90 min. There was progressive inhibition by 3 uM aspirin during incubation for 270 min. By the end of this time there was also significant inhibition by 1 uM aspirin.

Name

Type

Language

ASPIRIN LYSINE

Common Name

English

LYSINE ACETYLSALICYLATE

Common Name

English

FLECTADOL

Brand Name

English

LASPAL

Brand Name

English

L-LYSINE ACETYLSALICYLATE

Common Name

English

ACETYLSALICYLIC ACID LYSINATE

Common Name

English

L-LYSINE, 2-(ACETYLOXY)BENZOATE (1:1)

Common Name

English

LYSINE ASPIRIN

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

33988