ASPIRIN LYSINE

US Approved OTC

First marketed in 1899

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H8O4.C6H14N2O2
Molecular Weight	326.345
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCCC[C@H](N)C(O)=O.CC(=O)OC1=C(C=CC=C1)C(O)=O

InChI

InChIKey=JJBCTCGUOQYZHK-ZSCHJXSPSA-N

InChI=1S/C9H8O4.C6H14N2O2/c1-6(10)13-8-5-3-2-4-7(8)9(11)12;7-4-2-1-3-5(8)6(9)10/h2-5H,1H3,(H,11,12);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1

HIDE SMILES / InChI

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/011483s029lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/11723249

Aspirin is a nonsteroidal anti-inflammatory drug. Aspirin is unique in this class of drugs because it irreversibly inhibits both COX-1 and COX-2 activity by acetylating a serine residue (Ser529 and Ser516, respectively) positioned in the arachidonic acid-binding channel, thus inhibiting the synthesis of prostaglandins and reducing the inflammatory response. The drug is used either alone or in combination with other compounds for the treatment of pain, headache, as well as for reducing the risk of stroke and heart attacks in patients with brain ischemia and cardiovascular diseases.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 1 30 Target ID: P23219\|\|\|Q5T7T7 Gene ID: 5742.0 Gene Symbol: PTGS1 Target Organism: Homo sapiens (Human) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/200671s000lbl.pdf	Inhibitor 8297		1.2 µM [IC50]
Prostaglandin G/H synthase 2 48 Target ID: P35354 Gene ID: 5743.0 Gene Symbol: PTGS2 Target Organism: Homo sapiens (Human) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/011483s029lbl.pdf	Inhibitor 8297		5.2 µM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Pain 614 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/011483s029lbl.pdf	Primary	Approved 8429	SYNALGOS-DC Approved Use SYNALGOS-DC is a combination of dihydrocodeine, an opioid agonist, aspirin, a nonsteroidal anti-inflammatory drug, and caffeine, a methylxanthine, and is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Launch Date 1958
Headache 47 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a00c6776-e9ef-411b-9396-915c3787559a	Primary	Approved 8429	FIORINAL Approved Use FIORINAL is indicated for the relief of the symptom complex of tension (or muscle contraction) headache. Evidence supporting the efficacy and safety of Fiorinal in the treatment of multiple recurrent headaches is unavailable. Caution in this regard is required because butalbital is habit-forming and potentially abusable. Launch Date 1976
Myocardial infarction 121 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/200671s000lbl.pdf	Preventing	Approved 8429	DURLAZA Approved Use DURLAZA is a nonsteroidal anti-inflammatory drug indicated to reduce the risk of death and myocardial infarction (MI) in patients with chronic coronary artery disease, such as patients with a history of MI or unstable angina pectoris or with chronic stable angina and to reduce the risk of death and recurrent stroke in patients who have had an ischemic stroke or transient ischemic attack. Launch Date 2015
Stroke 144 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/20884_AGGRENOX_prntlbl.pdf	Preventing	Approved 8429	AGGRENOX Approved Use AGGRENOX is indicated to reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis. Launch Date 1999

C_max

Value	Dose	Co-administered	Analyte	Population
54.25 mg/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
4.84 mg/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
10.31 mg × h/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
5.12 mg × h/L EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
0.322 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, intravenous dose: 500 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
0.422 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24672263	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		ASPIRIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
68% REVIEW https://www.ncbi.nlm.nih.gov/pubmed/30115648			ASPIRIN plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1737 inducer 781	substrate 1037	substrate 1217 inducer 97

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OAT3 642	CYP1A2 1054 CYP2A6 543 CYP2B6 664 CYP2C8 693 CYP2C19 991 CYP2E1 667 esterase 72 UGT1A1 418 UGT1A3 422 UGT1A6 307 UGT1A7 236 UGT1A8 283 UGT1A9 380 UGT1A10 291 UGT2B4 249 UGT2B7 389 P-gp 1537	CYP2C19 293 CYP1A2 701 CYP2E1 128 ABCA1 18 P-gp 257

Drug as perpetrator

Target	Modality	Activity
CYP1A2 1692	inducer 1573 Sources: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1067/mcp.2003.14 Page: -	no
CYP2D6 1891	inducer 1573 Sources: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1067/mcp.2003.14 Page: -	no
CYP2E1 970	inducer 1573 Sources: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1067/mcp.2003.14 Page: -	no
ABCA1 18	inducer 1573 Sources: https://www.karger.com/Article/Abstract/321727 Page: -	yes
CYP2C19 1553	inducer 1573 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes
CYP3A4 1925	inducer 1573 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes
OAT3 644	inhibitor 3277 Sources: https://dmd.aspetjournals.org/content/42/6/996.short Page: -	yes
P-gp 1650	inducer 1573 Sources: https://pubmed.ncbi.nlm.nih.gov/11205285/ Page: -	yes

Drug as victim

Target	Modality	Activity	Metabolite
CYP1A2 1054	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP1A2 1054	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no	salicylic acid 18
CYP2A6 543	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2B6 664	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2B6 664	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no	salicylic acid 18
CYP2C19 991	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2C8 693	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2C9 1037	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP2D6 1217	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
CYP3A4 1737	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	no
P-gp 1537	substrate 3367 Sources: https://www.tandfonline.com/doi/full/10.1080/00498254.2020.1757785 Page: -	no
UGT1A8 283	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	no	salicylic acid 18
UGT2B4 249	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	no	salicylic acid 18
UGT2B7 389	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 1242 uM]	salicylic acid 18
UGT1A3 422	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 2337 uM]	salicylic acid 18
UGT1A7 236	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 278.6 uM]	salicylic acid 18
UGT1A6 307	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 40.7 uM]	salicylic acid 18
UGT1A1 418	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 683.1 uM]	salicylic acid 18
UGT1A10 291	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 698.2 uM]	salicylic acid 18
UGT1A9 380	substrate 3367 Sources: https://dmd.aspetjournals.org/content/34/2/199.short Page: -	yes [Km 94.2 uM]	salicylic acid 18
CYP2A6 543	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2C19 991	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2C8 693	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2C9 1037	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2D6 1217	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP2E1 667	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
CYP3A4 1737	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes	salicylic acid 18
esterase 72	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S0928098715001153 Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B1-00059	http://www.3bsc.com/index/pro_info.php?id=20271
AA Blocks	AA00I8UA	http://www.aablocks.com/goods/Goods/detail?id=AA00I8UA
AK Scientific, Inc. (AKSCI)	H740	http://www.aksci.com/item_detail.php?cat=H740
Aaron Chemicals	AR00I9M2	http://www.aaronchem.com/50-78-2
AbMole Bioscience	M5426	http://www.abmole.com/products/aspirin.html
Acadechem	ACDS-070196	http://www.acadechemical.com/product/144895
Achemica	ACMC-209kpz	http://www.achemica.com/prodinfo/?id=128318
Achemo Scientific Limited	AC-24217	http://www.achemo.com/search/?Keyword=50-78-2
Achemtek	0104-001327	http://www.achemtek.com/50-78-2
Acros Organics	AC158180500	https://www.fishersci.com/shop/products/acetylsalicylic-acid-99-acros-organics-1/AC158180500
Acros Organics	AC158185000	https://www.fishersci.com/shop/products/acetylsalicylic-acid-99-acros-organics-1/AC158185000
Acros Organics	AC158180025	https://www.fishersci.com/shop/products/acetylsalicylic-acid-99-acros-organics/AC158180025
Alfa Aesar	A12488	https://www.alfa.com/en/catalog/A12488/
Ambinter	Amb17757514	http://www.ambinter.com/reference/17757514
Angene	AGN-PC-0WACEM	http://www.angenechemical.com/productshow/AGN-PC-0WACEM.html
Anward	ANW-31125	http://www.anward.com/pro_result/20981
ApexBio Technology	A4013	http://www.apexbt.com/aspirin-acetylsalicylic-acid.html
Aurora Fine Chemicals LLC	A00.156.463	http://online.aurorafinechemicals.com/info?ID=A00.156.463
Aurora Fine Chemicals LLC	K00.801.915	http://online.aurorafinechemicals.com/info?ID=K00.801.915
Avantor Inc	TCA2262-25G	https://us.vwr.com/store/product/9983116/o-acetylsalicylic-acid-98-0-by-gc-titration-analysis
BOC Sciences	1173022-25-7	https://isotope.bocsci.com/product/acetylsalicylic-acid-13c-cas-1173022-25-7-343874.html
BOC Sciences	97781-16-3	https://www.bocsci.com/2-acetoxybenzoic-3-4-5-6-d4-acid-cas-97781-16-3-item-212339.html
BOC Sciences	921943-73-9	https://www.bocsci.com/acetylsalicylic-acid-d3-cas-921943-73-9-item-466862.html
BioChemPartner	BCP21790	http://www.biochempartner.com/50-78-2-BCP21790
BioCrick	BCC2097	http://www.biocrick.com/Aspirin-Acetylsalicylic-acid-BCC2097.html
Boerchem	BC221833	http://www.boerchem.com/?product_37473.html
Capot Chemical	20190	http://www.capotchem.com/en/20190.htm
Capot Chemical	PubChem20190	http://www.capotchem.com/en/20190.htm
Chem Scene	CS-2001	http://www.chemscene.com/50-78-2.html
ChemMol	49417180	http://www.chemmol.com/chemmol/49417180.html
ChemMol	99097732	http://www.chemmol.com/chemmol/99097732.html
Chemspace	CSSB00000210466	https://chem-space.com/CSSB00000210466
Clearsynth	CS-EG-00025	https://www.clearsynth.com/en/CSEG00025.html
Clearsynth	CS-ER-02340	https://www.clearsynth.com/en/CSER02340.html
Clearsynth	CS-T-01103	https://www.clearsynth.com/en/CST01103.html
Clearsynth	CS-T-47333	https://www.clearsynth.com/en/CST47333.html
DC Chemicals	DC8956	http://www.dcchemicals.com/product_show-Acetylsalicylic_acid.html
Debye Scientific	DS-017139	http://www.debyesci.com/cas_59096-14-9.html
Enamine	Z234893989	https://www.enaminestore.com/catalog/Z234893989
Finetech	FT-0655181	http://www.finetechnology-ind.com/prod/detail/pub/50-78-2.html
Finetech	FT-0661360	http://www.finetechnology-ind.com/prod/detail/pub/97781-16-3.html
Glentham Life Sciences	GL0865	http://www.glentham.com/products/product/GL0865/
Hairui	HR138909	http://www.hairuichem.com/en/product/50-78-2.html
LGC Standards	DRE-C10024000	https://www.lgcstandards.com/US/en/p/DRE-C10024000
LGC Standards	LGCAMP0133.00-11	https://www.lgcstandards.com/US/en/p/LGCAMP0133.00-11
LGC Standards	LGCFOR0133.00	https://www.lgcstandards.com/US/en/p/LGCFOR0133.00
LGC Standards	MM0133.00-0250	https://www.lgcstandards.com/US/en/p/MM0133.00-0250
Lab Network	LN00223310	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00223310
Matrix Scientific	134531	https://www.matrixscientific.com/134531.html
MedChem Express	HY-14654	https://www.medchemexpress.com/aspirin.html
MuseChem	A000653	https://www.musechem.com/product/A000653.html
Oakwood	101923	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=130521&ExtHyperLink=1
Parchem	30462	http://www.parchem.com/chemical-supplier-distributor/Aspirin-USP-2080B--020462.aspx
Parchem	12326	http://www.parchem.com/chemical-supplier-distributor/Aspirin-USP-26-002326.aspx
Parchem	30461	http://www.parchem.com/chemical-supplier-distributor/Aspirin-USP-3080--020461.aspx
Selleck Chemicals	S3017	http://www.selleckchem.com/products/aspirin-acetylsalicylic-acid.html
Sigma-Aldrich	239631_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/239631?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A0200000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/a0200000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A2093_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/a2093?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A3160_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/a3160?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1044006_USP	https://www.sigmaaldrich.com/catalog/product/usp/1044006?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S054539	http://www.sinfoobiotech.com/product/1057937
Smolecule	S519564	http://www.smolecule.com/products/s519564
Synthetic Heterocycles	AFA100669	http://www.synhet.com/products/AFA100669
TCI (Tokyo Chemical Industry)	A2262	http://www.tcichemicals.com/eshop/en/us/commodity/A2262/index.html
THE BioTek	bt-260267	https://www.thebiotek.com/product/inhibitors/bt-260267
Tocris	4092	https://www.tocris.com/products/aspirin_4092
Vitas-M Laboratory	BBL005469	http://www.request.vitasmlab.biz/index.php?option=com_search_stk&Itemid=22&stk=BBL005469&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
VladaChem	VL271248-100G	https://www.vladachem.com/product.php?products=50-78-2
Yuhao Chemical	RT12808	http://www.chemyuhao.com/50-78-2.html
abcr GmbH	AB113303	http://www.abcr.com/shop/en/AB113303
eNovation Chemicals	D408997	http://www.enovationchem.com/productDetails.asp?productID=D408997
iChemical	EBD47326	http://www.ichemical.com/products/50-78-2.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-3199019536	https://mcule.com/MCULE-3199019536/

PubMed

Title	Date	PubMed
Severe gastrointestinal hemorrhage and anemia after therapeutic doses of aspirin in normal children.	1976 Mar	1082021
Iron deficiency anaemia and aspirin use in old age.	1999 Sep	10756616
Sleep attacks (sleep episodes) with pergolide.	2000 Apr 15	10776749
Leukotriene receptor antagonists may prevent NSAID-induced exacerbations in patients with chronic urticaria.	2000 Aug	10982225
Pharmacotherapies for cocaine dependence.	2000 Dec	11123003
The discovery of aspirin: a reappraisal.	2000 Dec 23-30	11124191
Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.	2000 Dec 8	10993886
[Cholestatic hepatitis as a rare side effect of therapy with ticlopidine].	2000 Jul	10965556
Intermediate but not low doses of aspirin can suppress angiotensin-converting enzyme inhibitor-induced cough.	2000 Jul	10933569
An uncommon case of fluid retention simulating a congestive heart failure after aspirin consumption.	2000 Jul	10910377
Symptomatic secondary hemorrhagic transformation of ischemic Wallenberg's syndrome.	2000 Jun	10929277
Indications for early aspirin use in acute ischemic stroke : A combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groups.	2000 Jun	10835439
Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates.	2000 Jun 16	10860828
Aspirin-associated intracerebral hemorrhage: clinical and radiologic features.	2000 Jun 27	10881256
[Aspirin-induced angioedema of the nape of the neck with naproxen cross-reaction: a case report].	2000 May	10896977
Clinical, biochemical, and genetic characterization of a novel estrogen-dependent inherited form of angioedema.	2000 Sep	10984376
The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation.	2000 Sep	10942736
Aspirin induces apoptosis through mitochondrial cytochrome c release.	2000 Sep 1	11034327
Novel platelet inhibitors.	2001	11160773
Collagen as a model system to investigate the use of aspirin as an inhibitor of protein glycation and crosslinking.	2001 Apr	11006510
Cardiac risk factors, medication, and recurrent clinical events after acute coronary disease; a prospective cohort study.	2001 Feb	11161949
Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions.	2001 Feb	11161072
A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs.	2001 Feb	11160645
Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II).	2001 Feb	11157179
Antiplatelet drugs for prevention of pre-eclampsia and its consequences: systematic review.	2001 Feb 10	11159655
Systematic review of long term anticoagulation or antiplatelet treatment in patients with non-rheumatic atrial fibrillation.	2001 Feb 10	11159653
Addition of hydrophilic and lipophilic compounds of biological relevance to the monoolein/water system. I. Phase behavior.	2001 Jan	11163344
Present treatment options for unstable angina and non-Q-wave myocardial infarction.	2001 Jan	11161130
Antithrombotic agents in coronary artery disease.	2001 Jan	11157652
Gastric mucosal resistance to acute injury in experimental portal hypertension.	2001 Jan	11156591
Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA.	2001 Jan	11153776
The PlA polymorphism of glycoprotein IIIa functions as a modifier for the effect of estrogen on platelet aggregation.	2001 Jan	11151063
Endogenous nitric oxide and prostaglandins synergistically counteract thromboembolism in arterioles but not in venules.	2001 Jan	11145949
Disaggregation of in vitro preformed platelet-rich clots by abciximab increases fibrin exposure and promotes fibrinolysis.	2001 Jan	11145946
Low-dose aspirin therapy and periodontal attachment loss in ex- and non-smokers.	2001 Jan	11142665
Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses.	2001 Jan	11141472
[Leukocytoclastic vasculitis associated with ticlopidine].	2001 Jan	11141463
Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs.	2001 Jan	11138826
Prevention of pre-eclampsia: status and perspectives 2000.	2001 Jan	11134820
Hemoglobin and methemoglobin concentrations after large-dose infusions of diaspirin cross-linked hemoglobin.	2001 Jan	11133598
Effect of acetylsalicylic acid on endogenous I kappa B kinase activity in lung epithelial cells.	2001 Jan	11133489
Another reason for taking aspirin.	2001 Jan	11133488
Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid.	2001 Jan	11133261
Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement.	2001 Jan	11119474
Increased platelet reactivity and significant changes in coagulation markers after cavopulmonary connection.	2001 Jan	11119465
Salicylate and cocaine: interactive toxicity during chicken mid-embryogenesis.	2001 Jan 15	11163537
Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism.	2001 Jan 15	11145657
Blood donations and risk of coronary heart disease in men.	2001 Jan 2	11136685
Drug Points: tachycardia associated with moxifloxacin.	2001 Jan 6	11141146
The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa.	2001 Mar 9	11085996

Patents

Sample Use Guides

In Vivo Use Guide

Severe pain: Initiate treatment with two capsules (1 capsule contains 16 mg dihydrocodeine bitartrate, 356.4 mg aspirin, and 30 mg caffeine) orally every 4 hours as needed for pain. Headache: One or 2 capsules (1 capsule contains 50 mg butalbital, 325 mg aspirin and 40 mg caffeine) every 4 hours. Total daily dose should not exceed 6 capsules. Prevention of stoke and heart attacks: the recommended dose is one capsule of aspirin (162.5 mg) once daily. Take the capsules with a full glass of water at the same time each day. Prevention of stroke (in combination with dipyridamole): the recommended dose is one capsule (200 mg dipyridamole and 25 mg aspirin) given orally twice daily.

Route of Administration: Enteral

In Vitro Use Guide

Human platelet-rich plasma was incubated with various aspirin concentrations (10, 20, 50, 100, 200, 300, 400, 500 uM) at 37C for up to 4.5 h. Platelet aggregation and thromboxane generation were measured. Inhibition of platelet aggregation and thromboxane formation by 10 uM aspirin was maximal by 90 min. There was progressive inhibition by 3 uM aspirin during incubation for 270 min. By the end of this time there was also significant inhibition by 1 uM aspirin.

Name

Type

Language

ASPIRIN LYSINE

Common Name

English

LYSINE ACETYLSALICYLATE

Common Name

English

FLECTADOL

Brand Name

English

LASPAL

Brand Name

English

L-LYSINE ACETYLSALICYLATE

Common Name

English

ACETYLSALICYLIC ACID LYSINATE

Common Name

English

L-LYSINE, 2-(ACETYLOXY)BENZOATE (1:1)

Common Name

English

LYSINE ASPIRIN

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

33988