U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H21O4P
Molecular Weight 368.3628
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRI-O-CRESYL PHOSPHATE

SMILES

CC1=CC=CC=C1OP(=O)(OC2=CC=CC=C2C)OC3=CC=CC=C3C

InChI

InChIKey=YSMRWXYRXBRSND-UHFFFAOYSA-N
InChI=1S/C21H21O4P/c1-16-10-4-7-13-19(16)23-26(22,24-20-14-8-5-11-17(20)2)25-21-15-9-6-12-18(21)3/h4-15H,1-3H3

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
Impairment of glutamate signaling in mouse central nervous system neurons in vitro by tri-ortho-cresyl phosphate at noncytotoxic concentrations.
2014-11
Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth.
2013-08-09
Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants.
2013-03-25
Biochemical, histopathological and clinical evaluation of delayed effects caused by methamidophos isoforms and TOCP in hens: ameliorative effects using control of calcium homeostasis.
2012-12-08
Involvement of neuropathy target esterase in tri-ortho-cresyl phosphate-induced testicular spermatogenesis failure and growth inhibition of spermatogonial stem cells in mice.
2012-05-20
Changes in beclin-1 and micro-calpain expression in tri-ortho-cresyl phosphate-induced delayed neuropathy.
2012-05-05
Acute airway irritation of methyl formate in mice.
2012-02
Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.
2011-09-01
Exposure to airborne organophosphates originating from hydraulic and turbine oils among aviation technicians and loaders.
2010-12
Vacuoles in dorsal root Ganglia neurons: some questions.
2010-10
Development of diagnostics in the search for an explanation of aerotoxic syndrome.
2010-09-01
Neuropathological studies of chickens following exposure to chlorpyrifos.
2010-07
Vacuolation of sensory ganglion neuron cytoplasm in rats with long-term exposure to organophosphates.
2010-06
[Effect of phenylmethylsulfonyl fluoride pretreated on neurofilament subunits in spinal cords of hens administrated with tri-o-cresyl phosphate].
2010-04
Adulterated cocaine and lessons learned from the Jake walk blues.
2010-03
House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters.
2010-03
Toxic neuropathies.
2010-02-09
Organophosphorus-induced delayed neuropathy: a simple and efficient therapeutic strategy.
2010-02-01
Identification and characterization of biomarkers of organophosphorus exposures in humans.
2010
Thirteen-year follow-up of patients with tri-ortho-cresyl phosphate poisoning in northern suburbs of Xi'an in China.
2009-11
Allergic contact dermatitis from tricresyl phosphate.
2009-10-08
Phenylmethylsulfonyl fluoride protects against the degradation of neurofilaments in tri-ortho-cresyl phosphate (TOCP) induced delayed neuropathy.
2009-08-21
Effect of inhibition of neuropathy target esterase in mouse nervous tissues in vitro on phosphatidylcholine and lysophosphatidylcholine homeostasis.
2009-07-22
The homeostasis of phosphatidylcholine and lysophosphatidylcholine in nervous tissues of mice was not disrupted after administration of tri-o-cresyl phosphate.
2009-06
Amplify, amplify: shotgun proteomics boosts the signal for biomarker discovery.
2009-05
Neurofilaments degradation as an early molecular event in tri-ortho-cresyl phosphate (TOCP) induced delayed neuropathy.
2009-04-28
Radial neuropathy due to occupational lead exposure: Phenotypic and electrophysiological characteristics of five patients.
2009-04
Respiratory and dermal exposure to organophosphorus flame retardants and tetrabromobisphenol A at five work environments.
2009-02-01
Design of a small personal air monitor and its application in aircraft.
2009-01-15
The homeostasis of phosphatidylcholine and lysophosphatidylcholine was not disrupted during tri-o-cresyl phosphate-induced delayed neurotoxicity in hens.
2008-10-30
Worms and germs, drink and dementia: US health, society, and policy in the early 20th century.
2008-10
Growth inhibition and induction of G(1) phase cell cycle arrest in neuroblastoma SH-SY5Y cell by tri-ortho-cresyl phosphate.
2008-09
Determination of ortho-cresyl phosphate isomers of tricresyl phosphate used in aircraft turbine engine oils by gas chromatography and mass spectrometry.
2008-07-25
Shear small-angle light scattering studies of shear-induced concentration fluctuations and steady state viscoelastic properties.
2008-04-28
Effects of calcium gluconate and PMSF in the treatment of acute intoxication of chicken by TOCP.
2008-03
An Effective On-line Polymer Characterization Technique by Using SALS Image Processing Software and Wavelet Analysis.
2008
Axonal degeneration and neuropathy target esterase.
2007-09
Antibodies to neural proteins in organophosphorus-induced delayed neuropathy (OPIDN) and its amelioration.
2007-08-23
Verapamil abolished the enhancement of protein phosphorylation of brainstem mitochondria and synaptosomes from the hens dosed with tri-o-cresyl phosphate.
2007-07
[Determination of three organophosphorous flame retardants in textiles by gas chromatography].
2007-05
The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats.
1997-09-19
Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors.
1995-01
Histopathological assessment of triphenyl phosphite neurotoxicity in the hen.
1988
Dose-related beneficial and adverse effects of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens.
1986-04
Lymphocyte and brain neurotoxic esterase: dose and time dependence of inhibition in the hen examined with three organophosphorus esters.
1986-03-30
Assessment of the delayed neurotoxic potential of isopropyl triphenylphosphate using a nontraditional testing strategy.
1984
The time course of protection from delayed neurotoxicity induced by tri-o-cresyl phosphate and O,O-diisopropyl phosphorofluoridate by phenyl methyl sulfonyl fluoride in chickens.
1983-09
Jamaica ginger paralysis. Forty-seven-year follow-up.
1978-08
[Prevention of experimental neuritis induced by nitrofurantoin and triorthocresylphosphate].
1977-02
The Jake Walk Blues. A toxicologic tragedy mirrored in American popular music.
1976-12
Patents
Name Type Language
TRI-O-TOLYL PHOSPHATE
MI  
Preferred Name English
TRI-O-CRESYL PHOSPHATE
HSDB  
Systematic Name English
NSC-438
Code English
TRI-O-TOLYL PHOSPHATE [MI]
Common Name English
TRIS(2-METHYLPHENYL) PHOSPHATE
Systematic Name English
TRI-O-CRESYL PHOSPHATE [HSDB]
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
201-103-5
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY
EPA CompTox
DTXSID6032192
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY
WIKIPEDIA
Tri-o-cresyl phosphate
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY
MERCK INDEX
m11211
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY Merck Index
PUBCHEM
6527
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY
HSDB
4084
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY
FDA UNII
X8II18JD0A
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY
CAS
78-30-8
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY
NSC
438
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY
SMS_ID
300000053630
Created by admin on Mon Mar 31 19:53:18 GMT 2025 , Edited by admin on Mon Mar 31 19:53:18 GMT 2025
PRIMARY