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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H25ClN2O4S
Molecular Weight 484.995
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLPG-0974

SMILES

C[C@@]1(CCN1C(=O)C2=CSC3=CC=CC=C23)C(=O)N(CCCC(O)=O)CC4=CC(Cl)=CC=C4

InChI

InChIKey=MPMKMQHJHDHPBE-RUZDIDTESA-N
InChI=1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)/t25-/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
2014 Dec 11
Patents
Name Type Language
GLPG-0974
Code English
4-((((2R)-1-(BENZO(B)THIEN-3-YLCARBONYL)-2-METHYL-2-AZETIDINYL)CARBONYL)((3-CHLOROPHENYL)METHYL)AMINO)BUTANOIC ACID
Systematic Name English
BUTANOIC ACID, 4-((((2R)-1-(BENZO(B)THIEN-3-YLCARBONYL)-2-METHYL-2-AZETIDINYL)CARBONYL)((3-CHLOROPHENYL)METHYL)AMINO)-
Systematic Name English
4-(((R)-1-(BENZO(B)THIOPHENE-3-CARBONYL)-2-METHYL-AZETIDINE-2-CARBONYL)-(3-CHLORO-BENZYL)-AMINO)-BUTYRIC ACID
Systematic Name English
GLPG0974
Code English
Code System Code Type Description
DRUG BANK
DB15406
Created by admin on Sat Dec 16 13:37:58 GMT 2023 , Edited by admin on Sat Dec 16 13:37:58 GMT 2023
PRIMARY
PUBCHEM
57520598
Created by admin on Sat Dec 16 13:37:58 GMT 2023 , Edited by admin on Sat Dec 16 13:37:58 GMT 2023
PRIMARY
FDA UNII
X7REK61AIS
Created by admin on Sat Dec 16 13:37:58 GMT 2023 , Edited by admin on Sat Dec 16 13:37:58 GMT 2023
PRIMARY
SMS_ID
300000041460
Created by admin on Sat Dec 16 13:37:58 GMT 2023 , Edited by admin on Sat Dec 16 13:37:58 GMT 2023
PRIMARY
CAS
1391075-84-5
Created by admin on Sat Dec 16 13:37:58 GMT 2023 , Edited by admin on Sat Dec 16 13:37:58 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY
CAS
1391076-61-1
Created by admin on Sat Dec 16 13:37:58 GMT 2023 , Edited by admin on Sat Dec 16 13:37:58 GMT 2023
PRIMARY