2-HYDROXYSACLOFEN

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H12ClNO4S
Molecular Weight	265.714
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

NCC(O)(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

InChI

InChIKey=WBSMZVIMANOCNX-UHFFFAOYSA-N

InChI=1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
GABA B receptor 6	Antagonist 2,778		5.1 µM [IC50]

PubMed

Show entries

Title	Date	PubMed
2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors.	1988 Sep 23	2847092
Involvement of cholinergic systems in the deficit of place learning in Morris water maze task induced by baclofen in rats.	1995 Jun 19	7552356
Hypotensive and hypertensive effects of catecholamines intrathecally injected in anesthetized rats.	1996 Jun 10	8816361
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	1997 Mar 20	9069281
Activaton of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neurons.	2004	14698756

Showing 1 to 5 of 5 entries

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Patents

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Name

Type

Language

2-HYDROXYSACLOFEN

Common Name

English

2-HYDROXY-S-(-)-SACLOFEN

Common Name

English

3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PROPANE-1-SULFONIC ACID

Systematic Name

English

3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANE-1-SULFONIC ACID

Systematic Name

English

2-HYDROXY-SACLOFEN

Common Name

English

Showing 1 to 5 of 5 entries

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Show entries

Code System

Code

Type

Description

EPA CompTox

DTXSID30922408

PRIMARY

PUBCHEM

1564

PRIMARY

CAS

117354-64-0

PRIMARY

FDA UNII

X5IFR0UF10

PRIMARY

Showing 1 to 4 of 4 entries

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SUBSTANCE RECORD


					X5IFR0UF10

2-HYDROXYSACLOFEN