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Details

Stereochemistry RACEMIC
Molecular Formula C9H12ClNO4S
Molecular Weight 265.714
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2-HYDROXYSACLOFEN

SMILES

NCC(O)(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

InChI

InChIKey=WBSMZVIMANOCNX-UHFFFAOYSA-N
InChI=1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)

HIDE SMILES / InChI

Molecular Formula C9H12ClNO4S
Molecular Weight 265.714
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
5.1 µM [IC50]
PubMed

PubMed

TitleDatePubMed
2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors.
1988 Sep 23
Involvement of cholinergic systems in the deficit of place learning in Morris water maze task induced by baclofen in rats.
1995 Jun 19
Hypotensive and hypertensive effects of catecholamines intrathecally injected in anesthetized rats.
1996 Jun 10
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
1997 Mar 20
Activaton of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neurons.
2004
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 08:33:51 GMT 2023
Edited
by admin
on Sat Dec 16 08:33:51 GMT 2023
Record UNII
X5IFR0UF10
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2-HYDROXYSACLOFEN
Common Name English
2-HYDROXY-S-(-)-SACLOFEN
Common Name English
3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PROPANE-1-SULFONIC ACID
Systematic Name English
3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANE-1-SULFONIC ACID
Systematic Name English
2-HYDROXY-SACLOFEN
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID30922408
Created by admin on Sat Dec 16 08:33:51 GMT 2023 , Edited by admin on Sat Dec 16 08:33:51 GMT 2023
PRIMARY
PUBCHEM
1564
Created by admin on Sat Dec 16 08:33:51 GMT 2023 , Edited by admin on Sat Dec 16 08:33:51 GMT 2023
PRIMARY
CAS
117354-64-0
Created by admin on Sat Dec 16 08:33:51 GMT 2023 , Edited by admin on Sat Dec 16 08:33:51 GMT 2023
PRIMARY
FDA UNII
X5IFR0UF10
Created by admin on Sat Dec 16 08:33:51 GMT 2023 , Edited by admin on Sat Dec 16 08:33:51 GMT 2023
PRIMARY