ELEUTHEROSIDE D

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C34H46O18
Molecular Weight	742.7182
Optical Activity	UNSPECIFIED
Defined Stereocenters	14 / 14
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CO[C@H](C3=CC(OC)=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(OC)=C3)[C@@]1([H])CO[C@@H]2C5=CC(OC)=C(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(OC)=C5

InChI

InChIKey=FFDULTAFAQRACT-LHJOJEKWSA-N

InChI=1S/C34H46O18/c1-43-17-5-13(6-18(44-2)31(17)51-33-27(41)25(39)23(37)21(9-35)49-33)29-15-11-48-30(16(15)12-47-29)14-7-19(45-3)32(20(8-14)46-4)52-34-28(42)26(40)24(38)22(10-36)50-34/h5-8,15-16,21-30,33-42H,9-12H2,1-4H3/t15-,16+,21-,22-,23-,24-,25+,26+,27-,28-,29-,30-,33+,34+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3749339 | Fugh-Berman, A. (2003) The 5-minute Herb and Dietary Supplement Consult, p.114, retrieved from: https://books.google.ru/books?id=UCR3CtwmjHMC | Pizzorno, J.E. (2013) Textbook of Natural Medicine, p.728, retrieved from: https://books.google.ru/books?id=6cjgo1IixvEC

Eleutheroside D is an eleutheroside, a compound found in roots and stems of Eleutherococcus senticosus, the Siberian ginseng. Eleutheroside D and its diastereoisomer Eleutheroside E thought to be the most pharmacologically active eleutherosides. Placebo-controlled trial tested the effect of eleuthero extract (eleutheroside B in combination with eleutheroside B) on maximal working capacity by bicycle ergometry. Total work and time to exhaustion were significantly greater after eleuthero, compared with placebo phase and baseline.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Physical working capacity 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3749339	Primary		Phase I 428	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
eMolecules	106938050	https://orderbb.emolecules.com/search/#?query=106938050
mcule	MCULE-1654444762	https://mcule.com/MCULE-1654444762/
mcule	MCULE-1919236555	https://mcule.com/MCULE-1919236555/

PubMed

Title	Date	PubMed
Effect of Eleutherococcus senticosus extract on human physical working capacity.	1986 Jun	3749339
Application of bioreactor system for large-scale production of Eleutherococcus sessiliflorus somatic embryos in an air-lift bioreactor and production of eleutherosides.	2005 Nov 4	16095745
Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels.	2007	17612394
HPLC method for preliminary analysis of constituents in rat blood after oral administration of the extract of Acanthopanax senticosus.	2007 Dec	18008282
Pharmacokinetics of isofraxidin in rat plasma after oral administration of the extract of Acanthopanax senticosus using HPLC with solid phase extraction method.	2007 Sep	17827750
Protective effect of extract of Acanthopanax senticosus Harms on dopaminergic neurons in Parkinson's disease mice.	2012 May 15	22402244

Patents

Sample Use Guides

In Vivo Use Guide

Two ml of Eleutherococcus ethanol extract (0.24 mg of Eleutheroside D) once in the morning and again in the evening (0.5 h before meal) for 8 consecutive days

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

ELEUTHEROSIDE D

Common Name

English

4-((1S,3AR,4S,6AS)-4-(4-(.BETA.-D-GLUCOPYRANOSYLOXY)-3,5-DIMETHOXYPHENYL)TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1-YL)-2,6-DIMETHOXYPHENYL .BETA.-D-GLUCOPYRANOSIDE

Systematic Name

English

ELEUTHEROSIDE D:1-EPIMER

Common Name

English

ELEUTHEROSIDE D:1-EPIMER (CONSTITUENT OF ELEUTHERO) [DSC]

Common Name

English

Code System Code Type Description

FDA UNII

WVS8LR64R4