BUFETOLOL

Details

Stereochemistry	MIXED
Molecular Formula	C18H29NO4
Molecular Weight	323.4272
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC(O)COC1=C(OCC2CCCO2)C=CC=C1

InChI

InChIKey=AKLNLVOZXMQGSI-UHFFFAOYSA-N

InChI=1S/C18H29NO4/c1-18(2,3)19-11-14(20)12-22-16-8-4-5-9-17(16)23-13-15-7-6-10-21-15/h4-5,8-9,14-15,19-20H,6-7,10-13H2,1-3H3

HIDE SMILES / InChI

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/9502
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/international/adobiol.html and https://www.jstage.jst.go.jp/article/circj/80/3/80_CJ-66-0122/_pdf

Bufetolol is a β-adrenergic blocking agent. Bufetolol hydrochloride (a derivative of Bufetolol) is reported as an ingredient of Adobiol in Japan. It is used for the treatment of hypertension and hypertrophic cardiomyopathy.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 87 Target ID: CHEMBL2094118 Sources: http://www.sciencedirect.com/science/article/pii/S006577430860994X	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6132016	Primary		Approved 8429	Adobiol Approved Use Indications: cardiovascular disorders
Hypertrophic cardiomyopathy 8 Sources: https://www.jstage.jst.go.jp/article/circj/80/3/80_CJ-66-0122/_pdf	Primary		Approved 8429	Adobiol Approved Use For the treatment of Hypertrophic cardiomyopathy

PubMed

Title	Date	PubMed
Possible significance of the pharmacological differentiation of beta-blocking agents in hemodynamic effects in essential hypertension.	1983 Mar	6132016
Effects of beta-adrenoceptor blocking agents of N-tertiary butyl derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.	1983 Sep	6138715

Patents

Sample Use Guides

In Vivo Use Guide

Daily dose approved in Japan for the treatment of hypertrophic cardiomyopathy - 15mg/day

Route of Administration: Oral

In Vitro Use Guide

Bufetolol (10(-4) M) additionally prolonged the time for 90% repolarization of the dog Purkinje fibres.

Name

Type

Language

BUFETOLOL

Official Name

English

Y-6124 FREE BASE

Code

English

Y 6124 FREE BASE

Code

English

1-(TERT-BUTYLAMINO)-3-(O-((TETRAHYDROFURFURYL)OXY)PHENOXY)-2-PROPANOL

Common Name

English

BUFETOLOL [MI]

Common Name

English

Bufetolol [WHO-DD]

Common Name

English

bufetolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576