BUFETOLOL HYDROCHLORIDE

Details

Stereochemistry	MIXED
Molecular Formula	C18H29NO4.ClH
Molecular Weight	359.888
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)(C)NCC(O)COC1=C(OCC2CCCO2)C=CC=C1

InChI

InChIKey=DTAWWMIEZBHDDH-UHFFFAOYSA-N

InChI=1S/C18H29NO4.ClH/c1-18(2,3)19-11-14(20)12-22-16-8-4-5-9-17(16)23-13-15-7-6-10-21-15;/h4-5,8-9,14-15,19-20H,6-7,10-13H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	C18H29NO4
Molecular Weight	323.4272
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/9502
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/international/adobiol.html and https://www.jstage.jst.go.jp/article/circj/80/3/80_CJ-66-0122/_pdf

Bufetolol is a β-adrenergic blocking agent. Bufetolol hydrochloride (a derivative of Bufetolol) is reported as an ingredient of Adobiol in Japan. It is used for the treatment of hypertension and hypertrophic cardiomyopathy.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 87 Target ID: CHEMBL2094118 Sources: http://www.sciencedirect.com/science/article/pii/S006577430860994X	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6132016	Primary		Approved 8429	Adobiol Approved Use Indications: cardiovascular disorders
Hypertrophic cardiomyopathy 8 Sources: https://www.jstage.jst.go.jp/article/circj/80/3/80_CJ-66-0122/_pdf	Primary		Approved 8429	Adobiol Approved Use For the treatment of Hypertrophic cardiomyopathy

PubMed

Title	Date	PubMed
Possible significance of the pharmacological differentiation of beta-blocking agents in hemodynamic effects in essential hypertension.	1983 Mar	6132016
Effects of beta-adrenoceptor blocking agents of N-tertiary butyl derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.	1983 Sep	6138715

Patents

Sample Use Guides

In Vivo Use Guide

Daily dose approved in Japan for the treatment of hypertrophic cardiomyopathy - 15mg/day

Route of Administration: Oral

In Vitro Use Guide

Bufetolol (10(-4) M) additionally prolonged the time for 90% repolarization of the dog Purkinje fibres.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:36:23 GMT 2023` Edited by `admin` on `Fri Dec 15 18:36:23 GMT 2023`
Record UNII	LWE8W5792M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUFETOLOL HYDROCHLORIDE

Common Name

English

BUFETOLOL HYDROCHLORIDE [JAN]

Common Name

English

Bufetolol hydrochloride [WHO-DD]

Common Name

English

BUFETOLOL HYDROCHLORIDE [MI]

Common Name

English

Y-6124

Code

English

1-TERT-BUTYLAMINO-3-(2-TETRAHYDROFURFURYLOXYPHENOXY)PROPAN-2-OL HYDROCHLORIDE

Systematic Name

English

Y 6124

Code

English

2-PROPANOL, 1-((1,1-DIMETHYLETHYL)AMINO)-3-(2-((TETRAHYDRO-2-FURANYL)METHOXY)PHENOXY)-, HYDROCHLORIDE (1:1)

Systematic Name

English

BUFETOLOL HYDROCHLORIDE [MART.]

Common Name

English

BUFETOLOL HCL

Common Name

English

Code System Code Type Description

MERCK INDEX

m1045