U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H23N3O2
Molecular Weight 337.4155
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXIPEROMIDE

SMILES

O=C1NC2=C(C=CC=C2)N1C3CCN(CCOC4=CC=CC=C4)CC3

InChI

InChIKey=NVDBBGBUTKLRSN-UHFFFAOYSA-N
InChI=1S/C20H23N3O2/c24-20-21-18-8-4-5-9-19(18)23(20)16-10-12-22(13-11-16)14-15-25-17-6-2-1-3-7-17/h1-9,16H,10-15H2,(H,21,24)

HIDE SMILES / InChI
Oxiperomide was developed as a dopamine-receptor antagonist. Clinical trials have shown that this drug decreased dyskinesia in patients with Parkinson's disease receiving levodopa or other dopamine agonists without necessarily increasing Parkinsonian symptoms. However, information about the further development of this drug is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Neuroleptic-induced acute dyskinesias in rhesus monkeys.
1981
Patents

Sample Use Guides

Oxiperomide was given in 5 mg tablet doses twice daily, starting at 10 mg/day and increasing weekly by 5-10 mg/day intervals, up to 40 mg/day, until an optimal dose was achieved or side effects developed.
Route of Administration: Oral
Name Type Language
OXIPEROMIDE
INN   USAN  
USAN   INN  
Official Name English
oxiperomide [INN]
Common Name English
OXIPEROMIDE [USAN]
Common Name English
R-4714
Code English
R 4714
Code English
NSC-313681
Code English
1-[1-(2-Phenoxyethyl)-4-piperidyl]-2-benzimidazolinone
Systematic Name English
2H-BENZIMIDAZOL-2-ONE, 1,3-DIHYDRO-1-(1-(2-PHENOXYETHYL)-4-PIPERIDINYL)-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C38149
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
Code System Code Type Description
FDA UNII
WRO75M6RW2
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
NCI_THESAURUS
C66270
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
PUBCHEM
68634
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
NSC
313681
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
ChEMBL
CHEMBL2059304
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
EVMPD
SUB09534MIG
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
SMS_ID
100000083046
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
EPA CompTox
DTXSID30201306
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
INN
3451
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
CAS
5322-53-2
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY
MESH
C015411
Created by admin on Sat Dec 16 17:45:46 GMT 2023 , Edited by admin on Sat Dec 16 17:45:46 GMT 2023
PRIMARY