U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C17H19N3O
Molecular Weight 281.3523
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OFORNINE

SMILES

O=C(N1CCCCC1)C2=C(NC3=CC=NC=C3)C=CC=C2

InChI

InChIKey=YMODINPJYNHPTM-UHFFFAOYSA-N
InChI=1S/C17H19N3O/c21-17(20-12-4-1-5-13-20)15-6-2-3-7-16(15)19-14-8-10-18-11-9-14/h2-3,6-11H,1,4-5,12-13H2,(H,18,19)

HIDE SMILES / InChI
Ofornine is a vasodilator with antihypertensive activity. Experiments on rats have shown that ofornine reduced spontaneously hypertensive (SH) blood pressure through vasodilating and presynaptic adrenolytic activities, and that a dopaminergic mechanism may be involved. Information about the current use of this drug is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis of Ofornine mimics from natural product l-vasicine as anti-hypertensive agents.
2017 Feb 15
Name Type Language
OFORNINE
INN   USAN  
INN   USAN  
Official Name English
1-(N-4-Pyridylanthraniloyl)piperidine
Systematic Name English
OFORNINE [USAN]
Common Name English
WIN 48,049
Code English
ofornine [INN]
Common Name English
PIPERIDINE, 1-(2-(4-PYRIDINYLAMINO)BENZOYL)-
Systematic Name English
WIN-48049
Code English
Classification Tree Code System Code
NCI_THESAURUS C270
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
Code System Code Type Description
PUBCHEM
55754
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
SMS_ID
100000083291
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
INN
5605
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
EVMPD
SUB09423MIG
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
NCI_THESAURUS
C81526
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105194
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
USAN
W-23
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
FDA UNII
WK1LBP1F3L
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
ECHA (EC/EINECS)
289-346-3
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
EPA CompTox
DTXSID60236626
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY
CAS
87784-12-1
Created by admin on Sat Dec 16 17:09:00 GMT 2023 , Edited by admin on Sat Dec 16 17:09:00 GMT 2023
PRIMARY