Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H10FNO2 |
| Molecular Weight | 195.1903 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=CC=CC2=C1O[C@H]3CNC[C@@H]3O2
InChI
InChIKey=XSOUHEXVEOQRKJ-IUCAKERBSA-N
InChI=1S/C10H10FNO2/c11-6-2-1-3-7-10(6)14-9-5-12-4-8(9)13-7/h1-3,8-9,12H,4-5H2/t8-,9-/m0/s1
Fluparoxan (GR50360A) is a potent α2-adrenergic receptor antagonist used in the treatment of central neurodegenerative diseases, depression, the improvement of cognitive dysfunction in schizophrenia and in models of Alzheimer's disease. Fluparoxan was undergoing phase III trials as an antidepressant, but this development was also discontinued because of poor efficacy.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A new strategy for antidepressant prescription. | 2010 |
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| The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. | 2008-10-20 |
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| Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration. | 2008-10-02 |
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| Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling. | 2005-03-10 |
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| Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant? | 2005-03 |
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| Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. | 2000-02 |
|
| A comparative study of the reversal by different alpha 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine. | 1996-02 |
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| Code System | Code | Type | Description | ||
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DTXSID80146995
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100000080717
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6217
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72036
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C065161
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CHEMBL1765294
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WGA8E072GX
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105182-45-4
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SUB07725MIG
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C169993
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
