Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H10FNO2.ClH |
| Molecular Weight | 231.651 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.[H][C@]12CNC[C@]1([H])OC3=C(O2)C=CC=C3F
InChI
InChIKey=JNYKORXHNIRXSA-OZZZDHQUSA-N
InChI=1S/C10H10FNO2.ClH/c11-6-2-1-3-7-10(6)14-9-5-12-4-8(9)13-7;/h1-3,8-9,12H,4-5H2;1H/t8-,9-;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C10H10FNO2 |
| Molecular Weight | 195.1903 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Fluparoxan (GR50360A) is a potent α2-adrenergic receptor antagonist used in the treatment of central neurodegenerative diseases, depression, the improvement of cognitive dysfunction in schizophrenia and in models of Alzheimer's disease. Fluparoxan was undergoing phase III trials as an antidepressant, but this development was also discontinued because of poor efficacy.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A comparative study of the reversal by different alpha 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine. | 1996 Feb |
|
| Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. | 2000 Feb |
|
| Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant? | 2005 Mar |
|
| Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling. | 2005 Mar 10 |
|
| Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration. | 2008 Oct 2 |
|
| The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. | 2008 Oct 20 |
|
| A new strategy for antidepressant prescription. | 2010 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 04:49:38 GMT 2023
by
admin
on
Sat Dec 16 04:49:38 GMT 2023
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| Record UNII |
JDM10O8K10
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| Record Status |
Validated (UNII)
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| Record Version |
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9794625
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DTXSID90147019
Created by
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105227-44-9
Created by
admin on Sat Dec 16 04:49:38 GMT 2023 , Edited by admin on Sat Dec 16 04:49:38 GMT 2023
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JDM10O8K10
Created by
admin on Sat Dec 16 04:49:38 GMT 2023 , Edited by admin on Sat Dec 16 04:49:38 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |