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Details

Stereochemistry ACHIRAL
Molecular Formula C9H8N2S
Molecular Weight 176.238
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENTHIAZAMINE

SMILES

NC1=NC(=CS1)C2=CC=CC=C2

InChI

InChIKey=PYSJLPAOBIGQPK-UHFFFAOYSA-N
InChI=1S/C9H8N2S/c10-9-11-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H2,10,11)

HIDE SMILES / InChI

Description

Phenthiazamine was developed by Sekizawa et al. as a centrally acting anesthetic for fish. The time required to reduce the positive ganglionic potential in the sympathetic ganglion by phenthiazamine was prolonged in the presence of higher concentrations of Ca2+. The Ca2+-dependent action potential of guinea-pig ureter was reduced by this compound, whereas it did not affect the Na+-dependent action potential.

CNS Activity

CNS Active
3913
Curator's Comment: CNS active in fish and frog

Originator

Sekizawa, Y. et al.
2
Curator's Comment: Phenthiazamine was developed by Sekizawa et al. as a centrally acting anesthetic for fish.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Blocker
537
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Synthesis of a novel bistriazene reagent 4,4'-bis[3-(4-phenylthiazol-2-yl)triazenyl]biphenyl and its highly sensitive color reaction with mercury(II).
2007 Apr 30
4-Hex-yloxy-3-methoxy-benzaldehyde.
2009 May 14
Patents

Patents

06380180
2
06569880
2
JPH06293795A
2
JPH06306089A
2
JPS57188578A
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Increase in the amplitude of the slow P potential was found in all the specimens of Frog sympathetic ganglion with Phenthiazamine at 0.5 mM
Name Type Language
PHENTHIAZAMINE
Common Name English
NSC-2528
Code English
4-PHENYL-2-THIAZOLAMINE
Systematic Name English
THIAZOLE, 2-AMINO-4-PHENYL-
Systematic Name English
J37.311G
Code English
2-THIAZOLAMINE, 4-PHENYL-
Systematic Name English
Code System Code Type Description
CAS
2010-06-2
Created by admin on Sat Dec 16 08:03:54 GMT 2023 , Edited by admin on Sat Dec 16 08:03:54 GMT 2023
PRIMARY
NSC
2528
Created by admin on Sat Dec 16 08:03:54 GMT 2023 , Edited by admin on Sat Dec 16 08:03:54 GMT 2023
PRIMARY
PUBCHEM
40302
Created by admin on Sat Dec 16 08:03:54 GMT 2023 , Edited by admin on Sat Dec 16 08:03:54 GMT 2023
PRIMARY
FDA UNII
WF2822RIUS
Created by admin on Sat Dec 16 08:03:54 GMT 2023 , Edited by admin on Sat Dec 16 08:03:54 GMT 2023
PRIMARY
EPA CompTox
DTXSID4043804
Created by admin on Sat Dec 16 08:03:54 GMT 2023 , Edited by admin on Sat Dec 16 08:03:54 GMT 2023
PRIMARY
ECHA (EC/EINECS)
217-926-8
Created by admin on Sat Dec 16 08:03:54 GMT 2023 , Edited by admin on Sat Dec 16 08:03:54 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of PHENTHIAZAMINE
NIH
NCATS
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