PHENTHIAZAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8N2S
Molecular Weight	176.238
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC(=CS1)C2=CC=CC=C2

InChI

InChIKey=PYSJLPAOBIGQPK-UHFFFAOYSA-N

InChI=1S/C9H8N2S/c10-9-11-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H2,10,11)

HIDE SMILES / InChI

Molecular Formula	C9H8N2S
Molecular Weight	176.238
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6970807

Phenthiazamine was developed by Sekizawa et al. as a centrally acting anesthetic for fish. The time required to reduce the positive ganglionic potential in the sympathetic ganglion by phenthiazamine was prolonged in the presence of higher concentrations of Ca2+. The Ca2+-dependent action potential of guinea-pig ureter was reduced by this compound, whereas it did not affect the Na+-dependent action potential.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
calcium channel activity 11 Target ID: GO:0005262 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6970807	Blocker 555

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6970807	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Synthesis, physico-chemical investigations of Co(II), Ni(II) and Cu(II) complexes and their in vitro microbial, cytotoxic, DNA cleavage studies.	2010-06	20370554
4-Hex-yloxy-3-methoxy-benzaldehyde.	2009-05-14	21583143
Synthesis and Antibacterial Assessment of N-[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine.	2009-01	20177467
5-Methyl-2-[3-(4-phenylthiazol-2-yl)triazenyl]benzenesulfonic acid as a chromogenic reagent of N-cetylpyridinium chloride Synthesis, mechanism and analytical application.	2008-01-15	18371715
Synthesis of a novel bistriazene reagent 4,4'-bis[3-(4-phenylthiazol-2-yl)triazenyl]biphenyl and its highly sensitive color reaction with mercury(II).	2007-04-30	19071681
Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives.	2005-11-15	16115773
Complexes of ruthenium(III) with some 2-aminothiazole derivatives/synthesis, properties and pharmacological studies.	2004	15281618

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Increase in the amplitude of the slow P potential was found in all the specimens of Frog sympathetic ganglion with Phenthiazamine at 0.5 mM

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:51:27 GMT 2025` Edited by `admin` on `Mon Mar 31 21:51:27 GMT 2025`
Record UNII	WF2822RIUS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENTHIAZAMINE

Common Name

English

J37.311G

Preferred Name

English

NSC-2528

Code

English

4-PHENYL-2-THIAZOLAMINE

Systematic Name

English

THIAZOLE, 2-AMINO-4-PHENYL-

Systematic Name

English

2-THIAZOLAMINE, 4-PHENYL-

Systematic Name

English

Code System Code Type Description

CAS

2010-06-2