PHENTHIAZAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8N2S
Molecular Weight	176.238
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC(=CS1)C2=CC=CC=C2

InChI

InChIKey=PYSJLPAOBIGQPK-UHFFFAOYSA-N

InChI=1S/C9H8N2S/c10-9-11-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H2,10,11)

HIDE SMILES / InChI

Molecular Formula	C9H8N2S
Molecular Weight	176.238
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6970807

Phenthiazamine was developed by Sekizawa et al. as a centrally acting anesthetic for fish. The time required to reduce the positive ganglionic potential in the sympathetic ganglion by phenthiazamine was prolonged in the presence of higher concentrations of Ca2+. The Ca2+-dependent action potential of guinea-pig ureter was reduced by this compound, whereas it did not affect the Na+-dependent action potential.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
calcium channel activity 11 Target ID: GO:0005262 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6970807	Blocker 537

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6970807	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Complexes of ruthenium(III) with some 2-aminothiazole derivatives/synthesis, properties and pharmacological studies.	2004	15281618
Synthesis of a novel bistriazene reagent 4,4'-bis[3-(4-phenylthiazol-2-yl)triazenyl]biphenyl and its highly sensitive color reaction with mercury(II).	2007 Apr 30	19071681
Synthesis and Antibacterial Assessment of N-[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine.	2009 Jan	20177467
4-Hex-yloxy-3-methoxy-benzaldehyde.	2009 May 14	21583143
Synthesis, physico-chemical investigations of Co(II), Ni(II) and Cu(II) complexes and their in vitro microbial, cytotoxic, DNA cleavage studies.	2010 Jun	20370554

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Increase in the amplitude of the slow P potential was found in all the specimens of Frog sympathetic ganglion with Phenthiazamine at 0.5 mM

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:03:54 GMT 2023` Edited by `admin` on `Sat Dec 16 08:03:54 GMT 2023`
Record UNII	WF2822RIUS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENTHIAZAMINE

Common Name

English

NSC-2528

Code

English

4-PHENYL-2-THIAZOLAMINE

Systematic Name

English

THIAZOLE, 2-AMINO-4-PHENYL-

Systematic Name

English

J37.311G

Code

English

2-THIAZOLAMINE, 4-PHENYL-

Systematic Name

English

Code System Code Type Description

CAS

2010-06-2