Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H27N5O2S |
| Molecular Weight | 413.536 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CC1=CC=C(CSCCNC2=NC=C(CC3=CN=C(C)C=C3)C(=O)N2)O1
InChI
InChIKey=IKEHSFKMCULMKJ-UHFFFAOYSA-N
InChI=1S/C21H27N5O2S/c1-15-4-5-16(11-23-15)10-17-12-24-21(25-20(17)27)22-8-9-29-14-19-7-6-18(28-19)13-26(2)3/h4-7,11-12H,8-10,13-14H2,1-3H3,(H2,22,24,25,27)
Lupitidine (SKF 93479) is a histamine H2 receptor antagonist. Lupitidine is a potent inhibitor of gastric acid secretion with a long duration of action. It lacks an antiandrogenic effect. It enhances pituitary thyroid stimulating hormone drive by increasing thyroid hormone clearance. It exerts an antinociceptive effect in rodents.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Modulatory role of phosphoinositide 3-kinase in gastric acid secretion. | 2007-09 |
|
| Antinociceptive effects of H1- and H2-antihistaminics in mice. | 1993-09 |
|
| The perchlorate discharge test for examining thyroid function in rats. | 1987-11 |
|
| Repeated pentagastrin-stimulated gastric acid secretory tests carried out in the evaluation of the pharmacodynamics of a new histamine H2-receptor antagonist, SK&F 93479. | 1984-03 |
|
| The effects of histamine H2 receptor antagonists on androgen action in vivo and dihydrotestosterone binding to the rat prostate androgen receptor in vitro. | 1982-03-01 |
Patents
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Preferred Name | English | ||
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Official Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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WF028DWK9N
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SUB08619MIG
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5759
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C170142
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100000082252
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C101022
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83903-06-4
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CHEMBL69178
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DTXSID5043760
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Lupitidine
Created by
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4375468
Created by
admin on Mon Mar 31 19:18:36 GMT 2025 , Edited by admin on Mon Mar 31 19:18:36 GMT 2025
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
