Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H27N5O2S.3ClH |
Molecular Weight | 522.919 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.Cl.CN(C)CC1=CC=C(CSCCNC2=NC=C(CC3=CN=C(C)C=C3)C(=O)N2)O1
InChI
InChIKey=YMVSCUJJVSENIP-UHFFFAOYSA-N
InChI=1S/C21H27N5O2S.3ClH/c1-15-4-5-16(11-23-15)10-17-12-24-21(25-20(17)27)22-8-9-29-14-19-7-6-18(28-19)13-26(2)3;;;/h4-7,11-12H,8-10,13-14H2,1-3H3,(H2,22,24,25,27);3*1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C21H27N5O2S |
Molecular Weight | 413.536 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Lupitidine (SKF 93479) is a histamine H2 receptor antagonist. Lupitidine is a potent inhibitor of gastric acid secretion with a long duration of action. It lacks an antiandrogenic effect. It enhances pituitary thyroid stimulating hormone drive by increasing thyroid hormone clearance. It exerts an antinociceptive effect in rodents.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
The effects of histamine H2 receptor antagonists on androgen action in vivo and dihydrotestosterone binding to the rat prostate androgen receptor in vitro. | 1982 Mar 1 |
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The perchlorate discharge test for examining thyroid function in rats. | 1987 Nov |
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Antinociceptive effects of H1- and H2-antihistaminics in mice. | 1993 Sep |
|
Modulatory role of phosphoinositide 3-kinase in gastric acid secretion. | 2007 Sep |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:08:29 GMT 2023
by
admin
on
Fri Dec 15 18:08:29 GMT 2023
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Record UNII |
XKU5YY749W
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Record Status |
Validated (UNII)
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Record Version |
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CHEMBL69178
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DTXSID5020786
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C033275
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S-103
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C170143
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XKU5YY749W
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6321389
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72716-75-7
Created by
admin on Fri Dec 15 18:08:29 GMT 2023 , Edited by admin on Fri Dec 15 18:08:29 GMT 2023
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |