RISPENZEPINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H20N4O2
Molecular Weight	336.3877
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCCC(C1)C(=O)N2C3=CC=CC=C3NC(=O)C4=CC=CN=C24

InChI

InChIKey=LPLNSPKKMWHFAU-UHFFFAOYSA-N

InChI=1S/C19H20N4O2/c1-22-11-5-6-13(12-22)19(25)23-16-9-3-2-8-15(16)21-18(24)14-7-4-10-20-17(14)23/h2-4,7-10,13H,5-6,11-12H2,1H3,(H,21,24)

HIDE SMILES / InChI

Description
Sources: https://adisinsight.springer.com/drugs/800003718 | https://www.ncbi.nlm.nih.gov/pubmed/7663798 | https://www.ncbi.nlm.nih.gov/pubmed/2813498

Rispenzepine (DF 594) is a muscarinic receptor antagonist. Rispenzepine has high affinity for intestinal muscarinic receptors, with preferential action at M1 and M3 receptor subtypes. This drug shows potent inhibitory effects on intestinal motility. In guinea pigs, rispenzepine significantly increases acetylcholine release in the trachea. A phase II study to test efficacy in asthma patients has been discontinued.

Originator

Approval Year

Name

Type

Language

RISPENZEPINE

Official Name

English

rispenzepine [INN]

Common Name

English

5H-PYRIDO(2,3-B)(1,5)BENZODIAZEPIN-5-ONE, 6,11-DIHYDRO-11-((1-METHYL-3-PIPERIDINYL)CARBONYL)-

Systematic Name

English

6,11-DIHYDRO-11-((1-METHYL-3-PIPERIDINYL)CARBONYL)-5H-PYRIDO(2,3-B)(1,5)BENZODIAZEPIN-5-ONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698