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Details

Stereochemistry ABSOLUTE
Molecular Formula C23H32O3
Molecular Weight 356.4984
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ESTRADIOL 3-VALERATE

SMILES

[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(OC(=O)CCCC)C=C4

InChI

InChIKey=IFDPLCRWEBQEAJ-RBRWEJTLSA-N
InChI=1S/C23H32O3/c1-3-4-5-22(25)26-16-7-9-17-15(14-16)6-8-19-18(17)12-13-23(2)20(19)10-11-21(23)24/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/m1/s1

HIDE SMILES / InChI
Estradiol 3-valerate is used for quality control, toxicity studies and other analytical studies during commercial production of estradiol 17-valerate. Estradiol 17-valerate, a synthetic estrogen ester, which is applied in hormone replacement therapy.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Contrast medium-induced pulmonary vascular hyperpermeability is aggravated in a rat climacterium model.
2001 Mar
A comparative pharmacokinetic study of micronized estradiol valerate administered alone and in combination with medroxyprogesterone acetate in postmenopausal women.
2004 Oct
Hormone treatment of the adult transsexual patient.
2005
[Results' analysis of estradiol and progesterone supplementation in luteal phase vs progesterone alone in an assisted reproduction program].
2005 Apr
[Ovarian denervation and polycystic ovary].
2005 Feb
Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats.
2005 Nov 5
Rats with steroid-induced polycystic ovaries develop hypertension and increased sympathetic nervous system activity.
2005 Sep 7
Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats.
2006 Dec 15
Adenohypophyseal and hypothalamic GABA B receptor subunits are downregulated by estradiol in adult female rats.
2006 Jun 20
Effects on the male endocrine system of long-term treatment with gonadotropin-releasing hormone agonists and estrogens in male-to-female transsexuals.
2006 Mar
A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats.
2006 Oct
Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience.
2008 Jan
Effects of raloxifene and hormone replacement therapy on serum Th2 and Th3 type cytokine concentrations in healthy postmenopausal women: a randomised controlled trial.
2008 Jun
Short-term oral oestrogen therapy dissociates the growth hormone/insulin-like growth factor-I axis without altering energy metabolism in premenopausal women.
2009 Apr
Pattern recognition in menstrual bleeding diaries by statistical cluster analysis.
2009 Jul 16
[Effects of exposure to estradiol valerate in early pregnancy on the reproductive system development of F1 male rats].
2009 Sep
Effect of O/S/W process parameters on 17beta-EV loaded nanoparticles properties.
2010 Jan 1
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
ESTRADIOL 3-VALERATE
Common Name English
ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (17.BETA.)-, 3-PENTANOATE
Common Name English
ESTRADIOL, 3-VALERATE
Common Name English
ESTRADIOL VALERATE IMPURITY B [EP IMPURITY]
Common Name English
ESTRA-1,3,5(10)-TRIEN-17.BETA.-OL 3-VALERATE
Common Name English
3-HYDROXY-4-METHYLESTRA-1,3,5(10)-TRIEN-17.BETA.-YL PENTANOATE
Systematic Name English
Code System Code Type Description
FDA UNII
W8Z1P0RYK2
Created by admin on Sat Dec 16 04:55:47 GMT 2023 , Edited by admin on Sat Dec 16 04:55:47 GMT 2023
PRIMARY
EPA CompTox
DTXSID30176282
Created by admin on Sat Dec 16 04:55:47 GMT 2023 , Edited by admin on Sat Dec 16 04:55:47 GMT 2023
PRIMARY
PUBCHEM
14653378
Created by admin on Sat Dec 16 04:55:47 GMT 2023 , Edited by admin on Sat Dec 16 04:55:47 GMT 2023
PRIMARY
CAS
21881-45-8
Created by admin on Sat Dec 16 04:55:47 GMT 2023 , Edited by admin on Sat Dec 16 04:55:47 GMT 2023
PRIMARY