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Details

Stereochemistry ABSOLUTE
Molecular Formula C23H32O3
Molecular Weight 356.4984
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ESTRADIOL 3-VALERATE

SMILES

CCCCC(=O)OC1=CC2=C(C=C1)[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3CC2

InChI

InChIKey=IFDPLCRWEBQEAJ-RBRWEJTLSA-N
InChI=1S/C23H32O3/c1-3-4-5-22(25)26-16-7-9-17-15(14-16)6-8-19-18(17)12-13-23(2)20(19)10-11-21(23)24/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/m1/s1

HIDE SMILES / InChI

Molecular Formula C23H32O3
Molecular Weight 356.4984
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Estradiol 3-valerate is used for quality control, toxicity studies and other analytical studies during commercial production of estradiol 17-valerate. Estradiol 17-valerate, a synthetic estrogen ester, which is applied in hormone replacement therapy.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Effect of O/S/W process parameters on 17beta-EV loaded nanoparticles properties.
2010-01-01
[Effects of exposure to estradiol valerate in early pregnancy on the reproductive system development of F1 male rats].
2009-09
Pattern recognition in menstrual bleeding diaries by statistical cluster analysis.
2009-07-16
Short-term oral oestrogen therapy dissociates the growth hormone/insulin-like growth factor-I axis without altering energy metabolism in premenopausal women.
2009-04
Effects of raloxifene and hormone replacement therapy on serum Th2 and Th3 type cytokine concentrations in healthy postmenopausal women: a randomised controlled trial.
2008-06
Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience.
2008-01
Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats.
2006-12-15
A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats.
2006-10
Adenohypophyseal and hypothalamic GABA B receptor subunits are downregulated by estradiol in adult female rats.
2006-06-20
Effects on the male endocrine system of long-term treatment with gonadotropin-releasing hormone agonists and estrogens in male-to-female transsexuals.
2006-03
Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo A 5-day sub-acute pharmacodynamic study with ovariectomized rats.
2005-11-05
Rats with steroid-induced polycystic ovaries develop hypertension and increased sympathetic nervous system activity.
2005-09-07
[Results' analysis of estradiol and progesterone supplementation in luteal phase vs progesterone alone in an assisted reproduction program].
2005-04
[Ovarian denervation and polycystic ovary].
2005-02
Hormone treatment of the adult transsexual patient.
2005
A comparative pharmacokinetic study of micronized estradiol valerate administered alone and in combination with medroxyprogesterone acetate in postmenopausal women.
2004-10
Contrast medium-induced pulmonary vascular hyperpermeability is aggravated in a rat climacterium model.
2001-03
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:25:07 GMT 2025
Edited
by admin
on Mon Mar 31 21:25:07 GMT 2025
Record UNII
W8Z1P0RYK2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ESTRADIOL 3-VALERATE
Common Name English
ESTRA-1,3,5(10)-TRIEN-17.BETA.-OL 3-VALERATE
Preferred Name English
ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (17.BETA.)-, 3-PENTANOATE
Common Name English
ESTRADIOL, 3-VALERATE
Common Name English
ESTRADIOL VALERATE IMPURITY B [EP IMPURITY]
Common Name English
3-HYDROXY-4-METHYLESTRA-1,3,5(10)-TRIEN-17.BETA.-YL PENTANOATE
Systematic Name English
Code System Code Type Description
FDA UNII
W8Z1P0RYK2
Created by admin on Mon Mar 31 21:25:07 GMT 2025 , Edited by admin on Mon Mar 31 21:25:07 GMT 2025
PRIMARY
EPA CompTox
DTXSID30176282
Created by admin on Mon Mar 31 21:25:07 GMT 2025 , Edited by admin on Mon Mar 31 21:25:07 GMT 2025
PRIMARY
PUBCHEM
14653378
Created by admin on Mon Mar 31 21:25:07 GMT 2025 , Edited by admin on Mon Mar 31 21:25:07 GMT 2025
PRIMARY
CAS
21881-45-8
Created by admin on Mon Mar 31 21:25:07 GMT 2025 , Edited by admin on Mon Mar 31 21:25:07 GMT 2025
PRIMARY