PANCOPRIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H24ClN3O2
Molecular Weight	349.855
Optical Activity	( + / - )
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=C(Cl)C=C(C(=O)N[C@@H]2C[N@@]3CC[C@H]2CC3)C(OCC4CC4)=C1

InChI

InChIKey=DBQMQBCSKXTCIJ-MRXNPFEDSA-N

InChI=1S/C18H24ClN3O2/c19-14-7-13(17(8-15(14)20)24-10-11-1-2-11)18(23)21-16-9-22-5-3-12(16)4-6-22/h7-8,11-12,16H,1-6,9-10,20H2,(H,21,23)/t16-/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8804470 | https://www.ncbi.nlm.nih.gov/pubmed/1451737

Pancopride (LAS 30451) is a 5-hydroxytryptamine 3 receptor antagonist and was developed against cytotoxic drug-induced emesis. Pancopride was studied in clinical trials in patients treated with highly emetogenic chemotherapy. It was found a combination of Pancopride with dexamethasone was the most effective against chemotherapy-induced vomiting. However, information about the further development of this drug is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pancopride, a potent and long-acting 5-HT3 receptor antagonist, is orally effective against anticancer drug-evoked emesis.	1992 Nov 10	1451737
LAS 30451: a novel 5-HT3 antagonist.	1993	8427723
Single dose pharmacokinetics and tolerance of pancopride in healthy volunteers.	1995 Feb	7710444
Prevention of highly emetogenic chemotherapy-induced vomiting: a double blind, randomized crossover study to compare pancopride (LAS 30451) and pancopride plus dexamethasone.	1995 Nov-Dec	8804470
Lack of effect of a 5-HT3 antagonist, pancopride, on lower oesophageal sphincter pressure in volunteers.	1995 Oct	8554943

Sample Use Guides

In Vivo Use Guide

Pancopride (PNC) 0.2 mg/kg. i.v. 30 min before chemotherapy

Route of Administration: Intravenous

Name

Type

Language

PANCOPRIDE

Official Name

English

LAS-30451

Code

English

BENZAMIDE, 4-AMINO-N-1-AZABICYCLO(2.2.2)OCT-3-YL-5-CHLORO-2-(CYCLOPROPYLMETHOXY)-

Systematic Name

English

BENZAMIDE, 4-AMINO-N-1-AZABICYCLO(2.2.2)OCT-3-YL-5-CHLORO-2-(CYCLOPROPYLMETHOXY)-, (±)-

Systematic Name

English

LAS 30451

Code

English

(±)-4-AMINO-5-CHLORO-.ALPHA.-CYCLOPROPYL-N-3-QUINUCLIDINYL-O-ANISAMIDE

Common Name

English

pancopride [INN]

Common Name

English

PANCOPRIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885