Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2C6H5Hg.NO3.HO |
| Molecular Weight | 634.4 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[OH-].[O-][N+]([O-])=O.[Hg+]C1=CC=CC=C1.[Hg+]C2=CC=CC=C2
InChI
InChIKey=DQZCXZOUXZTNCU-UHFFFAOYSA-M
InChI=1S/2C6H5.2Hg.NO3.H2O/c2*1-2-4-6-5-3-1;;;2-1(3)4;/h2*1-5H;;;;1H2/q;;2*+1;-1;/p-1
Phenylmercuric nitrate is classified as an antimicrobial preservative. It is bactericidal against many Gram-positive and Gram-negative species. It is used as antimicrobial preservative mainly in ophthalmic preparations. Patients who used eye drops containing the preservative, phenylmercuric nitrate for from 3 to 15 years, developed a brownish pigmentation of the anterior capsule of the pupillary area. Special studies, including electron microprobe analysis and neutron activation analysis established the presence of mercury in a lens with mercurialentis. Phenylmercuric nitrate is also an effective spermicide, although its use in vaginal contraceptives is no longer recommended.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Ocular preservatives: associated risks and newer options. | 2009 |
|
| Eye drops preservative as the cause of corneal band keratopathy in long-term pilocarpine hydrochloride treatment. | 2012 Mar |
|
| Antifungal effect of ophthalmic preservatives phenylmercuric nitrate and benzalkonium chloride on ocular pathogenic filamentous fungi. | 2013 Jan |
|
| Temperature-mediated absorption of phenylmercuric nitrate on polyethylene and polypropylene containers in chloramphenicol eye drops. | 2014 Sep |
|
| A Rare Case Report of Conjunctival Cyst. | 2015 Nov |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Brand Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
m8683
Created by
admin on Sat Dec 16 02:18:40 GMT 2023 , Edited by admin on Sat Dec 16 02:18:40 GMT 2023
|
PRIMARY | Merck Index | ||
|
8003-05-2
Created by
admin on Sat Dec 16 02:18:40 GMT 2023 , Edited by admin on Sat Dec 16 02:18:40 GMT 2023
|
PRIMARY | |||
|
53384577
Created by
admin on Sat Dec 16 02:18:40 GMT 2023 , Edited by admin on Sat Dec 16 02:18:40 GMT 2023
|
PRIMARY | |||
|
W06K73CUGI
Created by
admin on Sat Dec 16 02:18:40 GMT 2023 , Edited by admin on Sat Dec 16 02:18:40 GMT 2023
|
PRIMARY | |||
|
2110
Created by
admin on Sat Dec 16 02:18:40 GMT 2023 , Edited by admin on Sat Dec 16 02:18:40 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD
