Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2C6H5Hg.NO3.HO |
Molecular Weight | 634.4 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[OH-].[O-][N+]([O-])=O.[Hg+]C1=CC=CC=C1.[Hg+]C2=CC=CC=C2
InChI
InChIKey=DQZCXZOUXZTNCU-UHFFFAOYSA-M
InChI=1S/2C6H5.2Hg.NO3.H2O/c2*1-2-4-6-5-3-1;;;2-1(3)4;/h2*1-5H;;;;1H2/q;;2*+1;-1;/p-1
Phenylmercuric nitrate is classified as an antimicrobial preservative. It is bactericidal against many Gram-positive and Gram-negative species. It is used as antimicrobial preservative mainly in ophthalmic preparations. Patients who used eye drops containing the preservative, phenylmercuric nitrate for from 3 to 15 years, developed a brownish pigmentation of the anterior capsule of the pupillary area. Special studies, including electron microprobe analysis and neutron activation analysis established the presence of mercury in a lens with mercurialentis. Phenylmercuric nitrate is also an effective spermicide, although its use in vaginal contraceptives is no longer recommended.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Beta-(1-4)-glucan hydrolase (Aspergillus niger) Sources: https://www.ncbi.nlm.nih.gov/pubmed/5862418 |
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Target ID: GO:0045277 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20287916 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Diagnostic | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9404570
Patch test - 0,01% aq.
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24710
The viable count of a plasmid-containing P. aeruginosa strain in Davis and Mingioli's minimal medium (DM) containing 10 ug/ml phenylmercuric nitrate fell by approximately 99% after 5 h.
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m8683
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8003-05-2
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SUBSTANCE RECORD