Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2C6H5Hg.NO3.HO |
| Molecular Weight | 634.4 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[OH-].[O-][N+]([O-])=O.[Hg+]C1=CC=CC=C1.[Hg+]C2=CC=CC=C2
InChI
InChIKey=DQZCXZOUXZTNCU-UHFFFAOYSA-M
InChI=1S/2C6H5.2Hg.NO3.H2O/c2*1-2-4-6-5-3-1;;;2-1(3)4;/h2*1-5H;;;;1H2/q;;2*+1;-1;/p-1
| Molecular Formula | HO |
| Molecular Weight | 17.0073 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H5Hg |
| Molecular Weight | 277.69 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | NO3 |
| Molecular Weight | 62.0049 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Phenylmercuric nitrate is classified as an antimicrobial preservative. It is bactericidal against many Gram-positive and Gram-negative species. It is used as antimicrobial preservative mainly in ophthalmic preparations. Patients who used eye drops containing the preservative, phenylmercuric nitrate for from 3 to 15 years, developed a brownish pigmentation of the anterior capsule of the pupillary area. Special studies, including electron microprobe analysis and neutron activation analysis established the presence of mercury in a lens with mercurialentis. Phenylmercuric nitrate is also an effective spermicide, although its use in vaginal contraceptives is no longer recommended.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Ocular preservatives: associated risks and newer options. | 2009 |
|
| Eye drops preservative as the cause of corneal band keratopathy in long-term pilocarpine hydrochloride treatment. | 2012 Mar |
|
| Antifungal effect of ophthalmic preservatives phenylmercuric nitrate and benzalkonium chloride on ocular pathogenic filamentous fungi. | 2013 Jan |
|
| Temperature-mediated absorption of phenylmercuric nitrate on polyethylene and polypropylene containers in chloramphenicol eye drops. | 2014 Sep |
|
| A Rare Case Report of Conjunctival Cyst. | 2015 Nov |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 02:18:40 GMT 2023
by
admin
on
Sat Dec 16 02:18:40 GMT 2023
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| Record UNII |
W06K73CUGI
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| Record Status |
Validated (UNII)
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