PHENYLMERCURIC NITRATE, BASIC

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C6H5Hg.NO3.HO
Molecular Weight	634.4
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PHENYLMERCURIC NITRATE, BASIC

Structure Search

SMILES

[OH-].[O-][N+]([O-])=O.[Hg+]C1=CC=CC=C1.[Hg+]C2=CC=CC=C2

InChI

InChIKey=DQZCXZOUXZTNCU-UHFFFAOYSA-M

InChI=1S/2C6H5.2Hg.NO3.H2O/c2*1-2-4-6-5-3-1;;;2-1(3)4;/h2*1-5H;;;;1H2/q;;2*+1;-1;/p-1

HIDE SMILES / InChI

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H5Hg
Molecular Weight	277.69
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	NO3
Molecular Weight	62.0049
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/867632 | https://www.ncbi.nlm.nih.gov/pubmed/16414700 | Kulshreshtha, A.K., Singh, O.N., Wall, G.M. (2009) Pharmaceutical Suspensions: From Formulation Development to Manufacturing, page 124, retrieved from: https://books.google.ru/books?id=JOf66-7G3VwC

Phenylmercuric nitrate is classified as an antimicrobial preservative. It is bactericidal against many Gram-positive and Gram-negative species. It is used as antimicrobial preservative mainly in ophthalmic preparations. Patients who used eye drops containing the preservative, phenylmercuric nitrate for from 3 to 15 years, developed a brownish pigmentation of the anterior capsule of the pupillary area. Special studies, including electron microprobe analysis and neutron activation analysis established the presence of mercury in a lens with mercurialentis. Phenylmercuric nitrate is also an effective spermicide, although its use in vaginal contraceptives is no longer recommended.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-(1-4)-glucan hydrolase (Aspergillus niger) 2 Target ID: Beta-(1-4)-glucan hydrolase (Aspergillus niger) Sources: https://www.ncbi.nlm.nih.gov/pubmed/5862418	Inhibitor 8297
respiratory chain complex IV 2 Target ID: GO:0045277 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20287916	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Mercury allergy 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11753893 https://www.ncbi.nlm.nih.gov/pubmed/9404570	Diagnostic		Not Provided 504	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B2-4366	http://www.3bsc.com/index/pro_info.php?id=79306
AHH Chemical co.,ltd	MT-22399	http://www.ahhchemical.com/product/MT-22399.html
Aaron Chemicals	AR003UEV	http://www.aaronchem.com/8003-05-2
Ambinter	Amb22732287	http://www.ambinter.com/reference/22732287
BOC Sciences	6509-33-7	https://www.bocsci.com/phenyl-mercuric-nitrate-cas-6509-33-7-item-191798.html
ChemTik	CTK8J2842
Chemieliva Pharmaceutical Co., Ltd	PBCM1339007
Chemspace	CSSB00020587421	https://chem-space.com/CSSB00020587421
Finetech	FT-0603233	http://www.finetechnology-ind.com/prod/detail/pub/55-68-5.html
Lab Seeker	SC-50165
MolPort	MolPort-035-944-311	https://www.molport.com/shop/molecule-link/MolPort-035-944-311
NovoSeek	16682924
NovoSeek	9840857
PubChem	16682924	https://pubchem.ncbi.nlm.nih.gov/compound/16682924
PubChem	9840857	https://pubchem.ncbi.nlm.nih.gov/compound/9840857
Tractus	TR-025362
Tractus	TRA-0203870
Yuhao Chemical	LQ0034	http://www.chemyuhao.com/55-68-5.html

PubMed

Title	Date	PubMed
Antifungal effect of ophthalmic preservatives phenylmercuric nitrate and benzalkonium chloride on ocular pathogenic filamentous fungi.	2013 Jan	23102555
Temperature-mediated absorption of phenylmercuric nitrate on polyethylene and polypropylene containers in chloramphenicol eye drops.	2014 Sep	24147942

Patents

Sample Use Guides

In Vivo Use Guide

Patch test - 0,01% aq.

Route of Administration: Topical

In Vitro Use Guide

The viable count of a plasmid-containing P. aeruginosa strain in Davis and Mingioli's minimal medium (DM) containing 10 ug/ml phenylmercuric nitrate fell by approximately 99% after 5 h.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:18:40 GMT 2023` Edited by `admin` on `Sat Dec 16 02:18:40 GMT 2023`
Record UNII	W06K73CUGI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENYLMERCURIC NITRATE, BASIC

Common Name

English

BASIC PHENYLMERCURIC NITRATE

Common Name

English

PHENMERZYL NITRATE

Brand Name

English

GYNE-MERFEN

Brand Name

English

MERPHENYL NITRATE

Common Name

English

MERFEN-STYLI

Brand Name

English

PHENYLMERCURIC NITRATE BASIC SALT [MI]

Common Name

English

NSC-2110

Code

English

PHE-MER-NITE

Brand Name

English

Code System Code Type Description

MERCK INDEX

m8683